Investigating the role of Bcl-2 in vision loss from age-related macular degeneration
Official title: Bcl-2, Subretinal Scar Formation and Neovascular AMD
Funded at University of Wisconsin-Madison · NIH-10733960 · Data updated 2026-11-12
This study is looking at how inflammation affects vision loss in older adults with age-related macular degeneration (AMD) and is exploring a protein called Bcl-2 to see if it plays a role in healing and could help find new treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $427,625 |
| NIH project number | 1R21EY034646-01A1 |
| Project ID | NIH-10733960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those diagnosed with neovascular age-related macular degeneration.
✕Less likely to help
Patients with early-stage AMD or those without any signs of neovascularization may not benefit from this research.
What this research studies
This research focuses on age-related macular degeneration (AMD), a condition that typically affects individuals over 60 and leads to vision loss. It aims to understand how inflammation contributes to the formation of subretinal scars and choroidal neovascularization (CNV) in neovascular AMD. The study will explore the role of Bcl-2, a protein that may prolong inflammation and affect the healing process in the eye. By examining how Bcl-2 influences mononuclear phagocytes and their role in these processes, the research seeks to uncover new insights into AMD progression and potential treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with age-related macular degeneration, potentially preserving vision and enhancing quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in AMD, but this specific approach focusing on Bcl-2 is relatively novel.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Sorenson, Christine M — University of Wisconsin-Madison
- Study coordinator: Sorenson, Christine M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.