Evaluating how cleft lip repair scars affect facial growth in small animals
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
This study is looking at how scars from cleft lip surgery affect the growth of the face in small animals, so we can learn how to improve treatments for kids with cleft lip and palate.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10642519 on NIH RePORTER |
What this research studies
This research investigates the effects of scarring from cleft lip repair on the growth and development of facial structures in small animal models. By creating a more accurate model that mimics human conditions, the study aims to better understand how early surgical interventions impact craniofacial development. The researchers will utilize innovative techniques to assess tissue regeneration and the long-term effects of scarring, which could lead to improved treatment strategies for children with cleft lip and palate. The findings may provide insights into better surgical practices and regenerative therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and children diagnosed with cleft lip and palate who may undergo surgical repair.
Not a fit: Patients with cleft lip who are not candidates for surgical intervention or those with other unrelated congenital anomalies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical techniques and treatments that enhance facial growth and development in children with cleft lip.
How similar studies have performed: While there have been studies on cleft lip repair, this approach using small animal models for craniofacial growth assessment is relatively novel and has not been extensively tested.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Li, Chenshuang — University of Pennsylvania
- Study coordinator: Li, Chenshuang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.