Understanding how specific signaling pathways affect scar formation during tendon healing
Official title: The function of mTORC1/Stat3 signaling in the regulation of fibrovascular scar formation during tendon healing
Funded at University of Pennsylvania · NIH-10999409 · Data updated 2026-11-12
This study is looking into how certain signals in the body affect the healing of tendon injuries, which can sometimes lead to pain and limited movement, with the goal of finding better ways to help people recover faster and more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $346,775 |
| NIH project number | 5R01AR079486-04 |
| Project ID | NIH-10999409 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with tendon injuries who are experiencing slow or incomplete healing.
✕Less likely to help
Patients with tendon injuries that have already healed completely or those without tendon injuries may not benefit from this research.
What this research studies
This research investigates the mechanisms behind fibrovascular scar formation that occurs during tendon healing, which can lead to reduced function and chronic pain. The study focuses on the roles of mTORC1 and Stat3 signaling pathways in regulating tendon cell behavior and the extracellular matrix during the healing process. By exploring these pathways, the research aims to identify potential targets for new treatments that could enhance tendon recovery and reduce complications. Patients may benefit from insights gained into how to improve healing outcomes after tendon injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for tendon injuries, enhancing healing and reducing chronic pain.
How similar studies have gone: Previous research has shown promising results in understanding signaling pathways in tissue healing, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Joeng, Kyu Sang — University of Pennsylvania
- Study coordinator: Joeng, Kyu Sang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.