Condition

Right Ventricular Dysfunction clinical trials and research

• 10Clinical trials
• 10NIH research projects
• 9Countries

Newest Right Ventricular Dysfunction clinical trials

All recruiting trials (10)

• Pulmonary Embolism Registry from Emergency Care to Long-Term Follow-Up

  This registry follows adults with acute pulmonary embolism to see how care is given in the real world and what happens over time.

  Recruiting at 16 sites Azienda Ospedaliero-Universitaria Careggi · Bagno a Ripoli, Tuscany and 15 other locations · NCT07855679

• Right ventricular–arterial coupling during fluid loading in ICU patients

  This study tests how the right ventricle handles fluid changes in critically ill adults to see how it affects blood flow and congestion.

  Recruiting CHU de Reims · Reims · NCT07537621

• Compare leadless and left bundle branch pacemakers for heart and valve function

  This study tests whether leadless pacemakers or left bundle branch area pacing better preserve heart and tricuspid valve function in adults needing a pacemaker.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT07534917

• Right-side heart function after pacemaker, ICD, or CRT implantation

  This project will see if right heart function changes in adults getting a pacemaker, ICD, or CRT by comparing imaging and a blood test before the device and six months later.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, FATIH · NCT07272395

• Feasibility assessment of treatments for right ventricular failure

  This study is testing if adding two different medications to standard care can help people with right heart failure and pulmonary hypertension feel better and if it's possible to do a bigger study in the future.

  Recruiting Phase 2 University of Alberta · Calgary, Alberta and 4 other locations · NCT06570473

• Using valsartan to help treat pulmonary hypertension

  This study is testing if the medication valsartan can help adults with pulmonary arterial hypertension feel better and improve their heart function.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT06053580

• Understanding heart function in COPD patients through exercise and imaging

  This study is testing how exercise affects heart function in people with COPD to see if it can help us understand their heart health better.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT05896579

• Effects of stenting on exercise capacity in patients with certain congenital heart defects

  This study is testing if a procedure to open blocked arteries can help people with certain heart defects, like d-TGA, ToF, and TA, exercise better.

  Recruiting UMC Utrecht · Amsterdam and 3 other locations · NCT05809310

• Inhaled milrinone and epoprostenol before heart surgery to ease weaning from bypass

  This trial tests whether inhaled milrinone and epoprostenol given before starting cardiopulmonary bypass can help people with right heart trouble during cardiac surgery.

  Recruiting Phase 2 Montreal Heart Institute · Montreal, Quebec · NCT05450328

• Right Ventricular Pacing in PAH

  This trial tests whether temporary pacing of the right ventricle can affect heart function in people with pulmonary arterial hypertension and right ventricular dysfunction.

  Recruiting University of California, San Francisco · San Francisco, California · NCT04194632

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeting the eNAMPT/TLR4 Pathway to Treat Pulmonary Arterial Hypertension and Protect the Right Heart

  Scientists are testing a new approach to treat pulmonary arterial hypertension by blocking a specific inflammatory signal (eNAMPT/TLR4) that affects blood vessels and the heart.

  NIH research University of Florida · Gainesville, United States · NIH-11412707

• Digital Heart Twin to Help Manage Right Heart Failure

  A patient-focused digital tool would use real-time heart and blood flow data to help doctors decide how to treat right heart failure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11345449

• How the c‑Src protein in heart mitochondria may weaken the right side of the heart in pulmonary hypertension

  Seeing if fixing how the mitochondrial protein c‑Src works can protect the right side of the heart in adults with pulmonary hypertension.

  NIH research Ocean State Research Institute, INC. · Providence, United States · NIH-11290408

• Detecting early right-heart changes and future lung high blood pressure in systemic sclerosis

  This project uses advanced heart ultrasound and machine learning to spot early right-heart changes that may predict pulmonary hypertension in people with systemic sclerosis.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11261524

• Blocking eNAMPT/TLR4 signaling to treat pulmonary arterial hypertension and right heart dysfunction

  Testing a new approach that blocks a protein called eNAMPT and its TLR4 signal to reduce blood-vessel scarring and help the right side of the heart in people with pulmonary arterial hypertension.

  NIH research University of Florida · Gainesville, United States · NIH-11224149

• Understanding how diabetes affects the right side of the heart

  This study is looking at how type 2 diabetes can affect the right side of the heart, which is often ignored, and it aims to understand the role of fatty acids and stress in causing this damage, so we can find better ways to help people with diabetes keep their hearts healthy.

  NIH research University of Wyoming · Laramie, United States · NIH-11192965

• Investigating how mitochondrial function affects heart problems in pulmonary hypertension

  This study is looking at how a specific protein in the energy factories of heart cells might contribute to heart problems in people with pulmonary hypertension, with the goal of finding new ways to help improve heart function for those affected.

  NIH research Ocean State Research Institute, INC. · Providence, United States · NIH-11078863

• Creating a digital model to improve treatment for right ventricular dysfunction

  This study is creating a digital tool that acts like a twin of your heart's right ventricle to help doctors better understand and treat heart problems, using real-time data from patients to improve care.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11070361

• Understanding how heart problems affect children with severe lung issues.

  This study is looking at how heart problems, like pulmonary hypertension and right ventricular dysfunction, affect children with acute respiratory distress syndrome (ARDS), to better understand their health and improve treatment for these kids.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11065521

• Detecting heart problems early in patients with systemic sclerosis

  This study is looking for better ways to spot pulmonary arterial hypertension (PAH) early in people with systemic sclerosis (SSc) by using new imaging techniques and smart computer tools, so that doctors can help patients sooner and improve their health.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11015054

Related topics

Quick answers

How many Right Ventricular Dysfunction clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (3 trials), Canada (2 trials), Netherlands (1 trial), Italy (1 trial), Poland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →