Investigating how mitochondrial function affects heart problems in pulmonary hypertension
Official title: Role of Mitochondrial c-Src in Right Ventricular Dysfunction in Pulmonary Hypertension
Funded at Ocean State Research Institute, INC. · NIH-11078863 · Data updated 2026-11-12
This study is looking at how a specific protein in the energy factories of heart cells might contribute to heart problems in people with pulmonary hypertension, with the goal of finding new ways to help improve heart function for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ocean State Research Institute, INC. NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | May 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $394,522 |
| NIH project number | 5R01HL169456-02 |
| Project ID | NIH-11078863 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with pulmonary hypertension who are experiencing right ventricular dysfunction.
✕Less likely to help
Patients with pulmonary hypertension who do not have right ventricular dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the role of mitochondrial c-Src in causing right ventricular dysfunction in patients with pulmonary hypertension (PH). It aims to explore how energy production in heart cells is affected by changes in mitochondrial function, particularly under the stress of high blood pressure in the lungs. By examining the mechanisms that lead to impaired heart function, the research seeks to identify potential new therapies that could improve outcomes for patients suffering from PH. The study will involve detailed analysis of heart cells and their energy-producing processes to uncover novel treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target right ventricular dysfunction in pulmonary hypertension, improving patient outcomes.
How similar studies have gone: While the specific approach of targeting mitochondrial function in right ventricular dysfunction is novel, similar studies have shown promise in other areas of cardiac research.
Where this research is happening
-
Ocean State Research Institute, INC.
Providence, United States Active
Researchers
- Principal investigator: Zhang, Peng — Ocean State Research Institute, INC.
- Study coordinator: Zhang, Peng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.