Digital Heart Twin to Help Manage Right Heart Failure

Who could benefit from this research

What this research studies

This project aims to build a digital a model of the heart’s hemodynamics that updates as new patient data come in, helping clinicians understand how the right ventricle will respond to treatments. By simulating the patient's cardiovascular system, doctors could see how options like fluids, devices, or surgery might affect heart function. The goal is to give clinicians a clearer, data-driven picture of the patient’s heart to guide decisions and improve outcomes.

Why it matters

Where this research is happening

• Massachusetts General Hospital
  Boston, United States Active

Researchers

• Principal investigator: Houstis, Nicholas E. — Massachusetts General Hospital
• Study coordinator: Houstis, Nicholas E.

Related research

Other NIH-funded projects on the same topics.

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  NIH research University of Florida · Gainesville, United States · NIH-11412707

• How the c‑Src protein in heart mitochondria may weaken the right side of the heart in pulmonary hypertension

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  NIH research Ocean State Research Institute, INC. · Providence, United States · NIH-11290408

• Detecting early right-heart changes and future lung high blood pressure in systemic sclerosis

  This project uses advanced heart ultrasound and machine learning to spot early right-heart changes that may predict pulmonary hypertension in people with systemic sclerosis.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11261524

• Blocking eNAMPT/TLR4 signaling to treat pulmonary arterial hypertension and right heart dysfunction

  Testing a new approach that blocks a protein called eNAMPT and its TLR4 signal to reduce blood-vessel scarring and help the right side of the heart in people with pulmonary arterial hypertension.

  NIH research University of Florida · Gainesville, United States · NIH-11224149

• Understanding how diabetes affects the right side of the heart

  This study is looking at how type 2 diabetes can affect the right side of the heart, which is often ignored, and it aims to understand the role of fatty acids and stress in causing this damage, so we can find better ways to help people with diabetes keep their hearts healthy.

  NIH research University of Wyoming · Laramie, United States · NIH-11192965

• Investigating how mitochondrial function affects heart problems in pulmonary hypertension

  This study is looking at how a specific protein in the energy factories of heart cells might contribute to heart problems in people with pulmonary hypertension, with the goal of finding new ways to help improve heart function for those affected.

  NIH research Ocean State Research Institute, INC. · Providence, United States · NIH-11078863

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.