Understanding how heart problems affect children with severe lung issues.
Official title: The Roles of Pulmonary Hypertension and Right Ventricular Dysfunction in Pediatric Acute Respiratory Distress Syndrome
Funded at Children's Hosp of Philadelphia · NIH-11065521 · Data updated 2026-11-12
This study is looking at how heart problems, like pulmonary hypertension and right ventricular dysfunction, affect children with acute respiratory distress syndrome (ARDS), to better understand their health and improve treatment for these kids.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 1, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $176,799 |
| NIH project number | 5K23HL153759-05 |
| Project ID | NIH-11065521 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are diagnosed with acute respiratory distress syndrome.
✕Less likely to help
Patients with ARDS who are older than 11 years or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the impact of pulmonary hypertension and right ventricular dysfunction on children suffering from acute respiratory distress syndrome (ARDS). It aims to identify how these cardiovascular issues contribute to the severity of ARDS and the overall outcomes for affected children. Using advanced imaging techniques like two-dimensional speckle tracking echocardiography, the study will assess heart function in pediatric patients. By analyzing blood biomarkers, the research seeks to enhance understanding of the relationship between heart and lung health in this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for children with ARDS, potentially reducing mortality and long-term complications.
How similar studies have gone: Previous research has indicated that understanding the cardiovascular aspects of ARDS can lead to better patient outcomes, suggesting that this approach has potential for success.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Himebauch, Adam S. — Children's Hosp of Philadelphia
- Study coordinator: Himebauch, Adam S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.