Condition

REM Sleep Behavior Disorder clinical trials and research

• 16Clinical trials
• 3NIH research projects
• 1New in 30 days
• 11Countries

Newest REM Sleep Behavior Disorder clinical trials

All recruiting trials (16)

• Ginger as a Modifier of Ghrelin Levels in Parkinson’s Disease and REM Sleep Behavior Disorder

  This study tests whether ginger capsules can raise ghrelin levels in people with Parkinson’s disease, REM sleep behavior disorder, and healthy controls.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge · NCT07882108

• Early PD signals in people with REM sleep behavior disorder

  This study tests whether people with REM sleep behavior disorder show early signs of Parkinson’s disease before classic symptoms appear.

  Recruiting Danish Research Centre for Magnetic Resonance · Hvidovre · NCT07790744

• Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns

  This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.

  Recruiting University of Cambridge · Cambridge, CB2 · NCT07786116

• Multimodal prospective cohort of Parkinsonism

  This project will try to track disease progression and improve diagnosis using imaging, clinical tests, and biological samples in people with parkinsonism, people with REM sleep behavior disorder, and healthy volunteers over five years.

  Recruiting Ruijin Hospital · Shanghai · NCT07553845

• Unmet needs of people with isolated REM sleep behavior disorder and their partners

  This project asks people with isolated REM sleep behavior disorder (iRBD) and their significant others about their informational, emotional, and practical needs using online questionnaires.

  Recruiting at 8 sites Universita di Verona · Bologna, Emilia-Romagna and 7 other locations · NCT07498452

• Aiming to see if adalimumab can slow brain changes linked to synucleinopathy in people with REM sleep behavior disorder

  This phase 2 trial tests whether the drug adalimumab, compared with placebo, can slow brain changes and progression toward Parkinson-like symptoms in people with idiopathic REM sleep behavior disorder.

  Recruiting at 10 sites Phase 2 Yale University · Los Angeles, California and 17 other locations · NCT06996652

• Exploring the effects of light and electrical stimulation on sleep disorders

  This study is testing if light therapy and brain stimulation can help people with sleep disorders like insomnia and narcolepsy get better sleep.

  Recruiting Second Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT06797284

• Using AI to predict Parkinson's risk in patients with REM sleep behavior disorder

  This study is testing if using artificial intelligence to analyze brain scans can help identify people with REM sleep behavior disorder who are at risk of developing Parkinson's disease.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06629207

• Behavioral therapy to reduce nightmares in REM sleep behavior disorder

  This trial will test whether a non-medication behavioral therapy delivered by videoconference can reduce frequent nightmares in adults with REM sleep behavior disorder while involving a family member.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06441864

• Exploring gut immunity's role in neurologic diseases

  This study is trying to see how immune cells in the gut might affect diseases like Multiple Sclerosis and Parkinson's by looking at tissue samples from people having a colonoscopy.

  Recruiting Yale University · North Haven, Connecticut · NCT06329453

• Investigating concussions and contact sports in patients with REM sleep behavior disorder

  This study is trying to see if people with REM sleep behavior disorder have more concussions and contact sports experience compared to those without the disorder.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, London · NCT06270290

• Increasing physical activity in patients at risk of Parkinson's disease using a smartphone app

  This study is testing a smartphone app to help people at risk of Parkinson's disease increase their physical activity and exercise intensity over two years.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT06193252

• National Parkinson's biobank with whole genome sequencing and patient-derived stem-cell testing

  This project will test whether combining whole genome sequencing and patient-derived stem cells can help find rare genetic changes linked to Parkinson's disease and REM sleep behavior disorder.

  Recruiting IRCCS San Raffaele · Milan, Italy · NCT05721911

• Examining brain changes in REM sleep behavior disorder

  This study is trying to see how the brains of people with REM sleep behavior disorder change over time compared to those without the condition.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05471960

• Identifying risk factors for REM Sleep Behavior Disorder

  This study is trying to find out what factors might lead to people developing REM Sleep Behavior Disorder by looking at their sleep patterns and movements during sleep.

  Recruiting at 2 sites University of Cagliari · Oggebbio, Verbania and 1 other locations · NCT05262543

• Observing the progression of synucleinopathies

  This study is tracking how synucleinopathies, a group of brain diseases, progress in adults with symptoms like dizziness when standing up to better understand their development over time.

  Recruiting at 8 sites NYU Langone Health · Boston, Massachusetts and 7 other locations · NCT01799915

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Early brain changes in people whose dream‑enacting sleep began or worsened after SSRI antidepressants

  This project looks for early signs of brain degeneration in people who started acting out their dreams after beginning serotonergic antidepressants like SSRIs.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11175319

• Understanding how brain injuries affect sleep disorders in veterans

  This study is looking at how brain injuries and PTSD might lead to sleep problems, specifically a condition called REM Sleep Behavior Disorder, in veterans, and it hopes to find out what causes these sleep issues and how they might relate to future health concerns.

  NIH research Portland VA Medical Center · Portland, United States · NIH-11109418

• Understanding early signs of neurodegeneration in patients with sleep behavior disorders

  This study is looking at how REM sleep behavior disorder (RBD) might be linked to early signs of dementia in people who have started taking certain antidepressants, and it hopes to help identify warning signs like changes in color vision or mild memory issues that could mean a higher risk for conditions like Dementia w

  NIH research University of Minnesota · Minneapolis, United States · NIH-10909338

Related topics

Quick answers

How many REM Sleep Behavior Disorder clinical trials are recruiting right now?

16, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (5 trials), Italy (3 trials), United Kingdom (3 trials), China (2 trials), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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