Multimodal prospective cohort of Parkinsonism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, prospective observational cohort enrolling 400 participants with parkinsonism, 120 with REM sleep behavior disorder (RBD), and 120 healthy controls with five years of follow-up. Participants will undergo multimodal assessments including neuroimaging, clinical rating scales, blood and other biological samples, cerebral blood flow testing, neurophysiology, tremor analysis, and voice/video recordings. The study aims to characterize longitudinal progression, identify factors linked to conversion from RBD to parkinsonism, and improve differentiation among parkinsonian disorders. All procedures are observational and designed to build biomarkers and diagnostic signatures rather than test an experimental treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For participants with rapid eye movement sleep behavior disorder:

* Meets the diagnostic criteria for rapid eye movement sleep behavior disorder established by the American Academy of Sleep Medicine
* Chinese citizen
* Age \>30 years and \<80 years
* Able to understand the study, show good compliance, and provide written informed consent personally or through a legal representative

For participants with Parkinsonism:

* Meets the diagnostic criteria for Parkinsonism established by the International Parkinson and Movement Disorder Society
* Chinese citizen
* Age \>30 years and \<80 years
* Able to understand the study, show good compliance, and provide written informed consent personally or through a legal representative

For healthy controls:

* No neurodegenerative disease, no history of head trauma or head surgery, no history of stroke, epilepsy, tumor, or psychiatric disease
* No metal implants or cardiac pacemaker
* No severe chronic disease or severe hepatic or renal insufficiency
* Chinese citizen
* Age \>30 years and \<80 years
* Education level of primary school or above
* Able to understand the study, show good compliance, and provide written informed consent personally or through a legal representative

Exclusion Criteria:

* Significant cognitive impairment (MMSE ≤23)
* Unable to sign the informed consent form or unable to complete study procedures for other reasons
* Any other condition that, in the opinion of the investigator, makes the participant unsuitable for this study

Where it's running

• Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Jun Liu, Professor
• Email: lj11128@rjh.com.cn
• Phone: +86-021-64370045

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.