Identifying risk factors for REM Sleep Behavior Disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify predictive risk factors for the conversion into idiopathic REM Sleep Behavior Disorder (iRBD). Participants diagnosed with iRBD will undergo video-polysomnographic recording to assess the loss of muscle atonia during REM sleep and related motor behaviors. The study seeks to better understand the prevalence and characteristics of RBD, which is often underdiagnosed. By analyzing data from multiple Italian universities, the research will contribute to the understanding of this sleep disorder.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: major of 18 years old
* iRBD diagnosis, according to diagnostic criteria of the ICSD second and third edition

Exclusion Criteria:

* Impossibility to provide or withdraw informed consent and inability to read, write and understand the purpose and modality of the study.

Where it's running

• IRCCS Auxologico Piancavallo
  Oggebbio, Verbania, Italy Recruiting
• Centro Interdipartimentale di Medicina del Sonno, Università degli studi di Cagliari
  Cagliari, Italy Recruiting

Study contacts

• Principal investigator: Monica Puligheddu, MD,PhD — University of Cagliari
• Study coordinator: Monica Puligheddu, MD, PhD
• Email: centrosonnoca@unica.it
• Phone: 070 5109 6016

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ginger as a Modifier of Ghrelin Levels in Parkinson’s Disease and REM Sleep Behavior Disorder

  This study tests whether ginger capsules can raise ghrelin levels in people with Parkinson’s disease, REM sleep behavior disorder, and healthy controls.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge · NCT07882108

• Early PD signals in people with REM sleep behavior disorder

  This study tests whether people with REM sleep behavior disorder show early signs of Parkinson’s disease before classic symptoms appear.

  Recruiting Danish Research Centre for Magnetic Resonance · Hvidovre · NCT07790744

• Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns

  This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.

  Recruiting University of Cambridge · Cambridge, CB2 · NCT07786116

• Multimodal prospective cohort of Parkinsonism

  This project will try to track disease progression and improve diagnosis using imaging, clinical tests, and biological samples in people with parkinsonism, people with REM sleep behavior disorder, and healthy volunteers over five years.

  Recruiting Ruijin Hospital · Shanghai · NCT07553845

• Unmet needs of people with isolated REM sleep behavior disorder and their partners

  This project asks people with isolated REM sleep behavior disorder (iRBD) and their significant others about their informational, emotional, and practical needs using online questionnaires.

  Recruiting at 8 sites Universita di Verona · Bologna, Emilia-Romagna and 7 other locations · NCT07498452

• Aiming to see if adalimumab can slow brain changes linked to synucleinopathy in people with REM sleep behavior disorder

  This phase 2 trial tests whether the drug adalimumab, compared with placebo, can slow brain changes and progression toward Parkinson-like symptoms in people with idiopathic REM sleep behavior disorder.

  Recruiting at 10 sites Phase 2 Yale University · Los Angeles, California and 17 other locations · NCT06996652

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.