Understanding early signs of neurodegeneration in patients with sleep behavior disorders
Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM sleep Behavior Disorder
This study is looking at how REM sleep behavior disorder (RBD) might be linked to early signs of dementia in people who have started taking certain antidepressants, and it hopes to help identify warning signs like changes in color vision or mild memory issues that could mean a higher risk for conditions like Dementia with Lewy bodies or Parkinson's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10909338 on NIH RePORTER |
What this research studies
This research investigates the connection between REM sleep behavior disorder (RBD) and early neurodegenerative changes, particularly in patients who have started serotonergic antidepressants. It aims to identify prodromal signs of dementia, such as impaired color vision and mild cognitive impairment, that may emerge in individuals with RBD. By analyzing these symptoms, the study seeks to better understand how RBD can indicate the risk of developing conditions like Dementia with Lewy bodies or Parkinson's disease. Patients will be monitored over time to assess the progression of symptoms and their relationship to neurodegeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing REM sleep behavior disorder, particularly those who have recently started serotonergic antidepressants.
Not a fit: Patients who do not have REM sleep behavior disorder or are not on serotonergic medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and intervention for patients at risk of developing neurodegenerative disorders.
How similar studies have performed: Previous research has indicated that early signs of neurodegeneration can be linked to sleep disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Howell, Michael J — University of Minnesota
- Study coordinator: Howell, Michael J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.