Condition

Malignant Glioma clinical trials and research

• 12Clinical trials
• 15NIH research projects
• 3Countries

Newest Malignant Glioma clinical trials

All recruiting trials (12)

• Dual-target CAR-NK therapy for adults with recurrent or progressive glioblastoma and other high-grade gliomas

  This study will try giving dual-target CAR-NK cells into the surgical cavity to see if they can help adults with recurrent or progressive glioblastoma or other high-grade gliomas.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07551336

• Dual-target CAR-NK cell therapy for recurrent glioblastoma and high-grade glioma

  This phase 1 study will test whether injecting dual-target CAR-NK cells into the brain is safe and can help adults with recurrent or progressive glioblastoma or other high-grade gliomas.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07480941

• Retifanlimab With or Without DFMO for Progressive High-Grade Gliomas

  This trial tests whether retifanlimab, with or without DFMO, is safe and may help treat progressive high-grade gliomas in adults.

  Recruiting Phase 1/2 Mayo Clinic · Rochester, Minnesota · NCT07468136

• T2* MRI and blood tests to predict progression of malignant gliomas

  This trial tests whether T2* MRI scans and blood biomarkers can help predict how WHO grade IV malignant gliomas will change or come back in adults.

  Recruiting University of Iowa · Iowa City, Iowa · NCT07447531

• Mapping electrical properties in the brain

  This study is testing new MRI methods to see if they can help doctors better understand and diagnose brain tumors by looking at the brain's electrical activity.

  Recruiting Mayo Clinic · Scottsdale, Arizona · NCT06470711

• Investigating the effects of DFMO and AMXT 1501 on brain tumor metabolism

  This study is testing how two drugs, DFMO and AMXT 1501, can change the metabolism of brain tumors in patients after surgery.

  Recruiting Early Phase 1 Mayo Clinic · Rochester, Minnesota · NCT05717153

• Using CARv3-TEAM-E T Cells to treat glioblastoma

  This study is testing the best dose of a new type of immune cell treatment for people with glioblastoma, a serious brain cancer, to see how safe and effective it is.

  Recruiting Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT05660369

• Using ultrasound to open the blood-brain barrier for treating brain tumors in children

  This study is testing if a special ultrasound device can safely help deliver chemotherapy directly to brain tumors in children to improve their treatment.

  Recruiting at 3 sites Phase 1 Assistance Publique - Hôpitaux de Paris · Paris and 2 other locations · NCT05293197

• Preoperative radiosurgery for high grade glioma treatment

  This study is testing if giving a high dose of radiation before surgery can help people with high-grade brain tumors feel better and live longer.

  Recruiting at 2 sites Phase 1 Mayo Clinic · Phoenix, Arizona and 1 other locations · NCT05030298

• Using MRI scans to personalize radiotherapy for high grade glioma

  This study tests if using regular MRI scans to track tumor changes can help doctors personalize radiation treatment for patients with high grade glioma to improve their outcomes.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04771806

• Non-invasive imaging to characterize gliomas

  This study is testing a new MRI method to see if it can help understand gliomas better by measuring certain substances in the tumor without needing any invasive procedures.

  Recruiting University of Miami · Miami, Florida · NCT03684109

• Using a special dye to improve surgery for brain tumors

  This study is testing a special dye that helps doctors see brain tumors better during surgery to improve outcomes for people with malignant glioma.

  Recruiting Phase 1/2 Stanford University · Palo Alto, California · NCT03510208

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Synergistic blood-brain barrier opening and targeted glioma treatment with pulsed electric fields

  A new approach uses tiny, rapid electric pulses to safely disrupt the brain's protective barrier and enhance targeted treatment for malignant glioma.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11453163

• Neural stem cells carrying cancer-killing viruses to treat brain cancer

  A study tests delivering a virus that specifically targets brain tumors using neural stem cells to reach cancer cells across the brain.

  NIH research Northwestern University · Chicago, United States · NIH-11402760

• Self-assembling camptothecin gel for local brain tumor treatment

  A Johns Hopkins-led study is testing a new injectable gel that releases a cancer drug over time to help treat glioblastoma after brain tumor surgery.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11389340

• Inhibiting IDH1 to Trigger Ferroptosis in Aggressive Brain Cancer

  Aimed at slowing hard-to-treat brain tumors by blocking a cancer-fueling enzyme (IDH1) in tumors that don’t have a common mutation, potentially making tumors easier to kill with radiation or immune therapies.

  NIH research Washington University · Saint Louis, United States · NIH-11355379

• Neural stem cell delivery of cancer‑killing virus for malignant brain tumors

  This work uses neural stem cells to carry cancer‑killing viruses into the brain to treat people with malignant glioma.

  NIH research Northwestern University · Chicago, United States · NIH-11187068

• Camptothecin nanofiber gel placed after brain tumor surgery

  This project is building a drug-releasing gel surgeons could place in the cavity after removing a malignant glioma to kill leftover cancer cells and help patients live longer.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11178652

• Targeting a protein called IDH1 to treat aggressive brain tumors

  This research explores a new way to treat aggressive brain tumors, called malignant glioma, by blocking a specific protein to trigger cancer cell death.

  NIH research Washington University · Saint Louis, United States · NIH-11123227

• Understanding how immune cells in the brain interact in glioblastoma

  This project explores how a type of immunotherapy might help patients with glioblastoma by changing the behavior of immune cells in the brain.

  NIH research Northwestern University · Chicago, United States · NIH-11110490

• Understanding how brain tumors interact with nerve cells

  This study is looking at how aggressive brain tumors called malignant gliomas interact with nearby nerve cells to find new ways to improve treatment for patients like you.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10949100

• Using special hydrogels with camptothecin to improve treatment for brain tumors.

  This study is testing a new way to deliver the cancer drug camptothecin directly to the brain after surgery for glioblastoma, with the hope of improving treatment and helping patients live longer.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10919803

• Using neural stem cells to deliver viruses that target and kill brain tumors.

  This study is testing a new way to treat malignant glioma, a tough type of brain cancer, by using special cells to deliver viruses that can help kill the cancer and boost the immune system, and it's for patients looking for new options to improve their survival.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10898585

• Targeting a specific enzyme to treat aggressive brain tumors.

  This study is looking at how blocking a specific enzyme called IDH1 might help slow down the growth of aggressive brain tumors by causing cancer cells to die in a new way, and it’s designed for patients with malignant gliomas that don’t have a certain mutation.

  NIH research Washington University · Saint Louis, United States · NIH-10896303

• Investigating the role of a specific microRNA in brain tumors

  This study is looking at how a tiny molecule called microRNA-10b affects the growth of glioblastoma, a tough type of brain cancer, to find new ways to help treat patients like you.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10892994

• Understanding how gut and tumor bacteria affect brain cancer

  This study is looking at how the bacteria in your gut and tumor might affect your immune system's response to treatments for glioblastoma, a tough type of brain cancer, and it hopes to find new ways to make these treatments work better for patients like you.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10814308

• Targeting a specific protein in brain tumors with CAR T cell therapy and nivolumab.

  This study is testing a new treatment for patients with recurring glioblastoma by using a special type of immune therapy called CAR T cell therapy, combined with another medication to help boost its effectiveness, and it's designed to see if this approach can safely improve how well the treatment works against the tumo

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-10793527

Related topics

Quick answers

How many Malignant Glioma clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (9 trials), China (2 trials), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 1/2: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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