Using immune therapy before surgery for recurrent glioblastoma
Neoadjuvant checkpoint blockade for recurrent glioblastoma
This study is looking at how giving a special immune therapy before surgery can help patients with recurrent glioblastoma fight their tumors better, and it will compare the results to the usual treatments given after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11062541 on NIH RePORTER |
What this research studies
This research investigates the use of immune therapy, specifically PD-1 blockade, before surgery in patients with recurrent glioblastoma. The approach aims to enhance the immune response against tumor cells by administering treatment prior to surgical intervention. The study will analyze the effects of this neoadjuvant therapy on tumor gene expression and overall patient survival compared to traditional post-surgery treatments. Patients will be monitored for changes in immune activity and tumor response throughout the treatment process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with recurrent glioblastoma who are eligible for surgical intervention.
Not a fit: Patients with non-recurrent glioblastoma or those who are not candidates for surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better treatment outcomes for patients with recurrent glioblastoma.
How similar studies have performed: Previous small trials have shown promising results with neoadjuvant PD-1 blockade in glioblastoma, indicating potential for this approach.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Prins, Robert M — University of California Los Angeles
- Study coordinator: Prins, Robert M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.