Condition

Recurrence clinical trials and research

• 22Clinical trials
• 122NIH research projects
• 14Countries

Newest Recurrence clinical trials

All recruiting trials (22)

• Non-Thermal Plasma Used During Surgery to Help Prevent Recurrent Chronic Subdural Hematoma

  A randomized trial tests whether applying non-thermal plasma during standard surgery to drain a chronic subdural hematoma can reduce recurrence within 6 months.

  Recruiting National Institute of Nuclear Research - Mexico · Ocoyoacac, State of Mexico · NCT07656818

• Intratumoral DNX-2401 for High-Grade Pediatric Brain Tumors

  This study tests whether a single injection of DNX-2401 into a pediatric brain tumor can help shrink the tumor and extend survival in kids and young adults with recurrent or refractory high-grade brain tumors.

  Recruiting Phase 2 Clinica Universidad de Navarra, Universidad de Navarra · Utrecht and 1 other locations · NCT07424092

• xDRIVE personalized tumor testing for Florida cancer patients

  This program will try a functional precision medicine and AI platform (xDRIVE) to help guide next treatment options for Florida patients with recurrent or refractory cancer, including children and people from underserved communities.

  Recruiting First Ascent Biomedical Inc. · Miami, Florida and 1 other locations · NCT07167381

• How exercise relates to health and cancer outcomes in adult survivors

  This project will see if exercising after treatment is linked to cancer outcomes and other health events in adults who have finished primary cancer therapy.

  Recruiting Memorial Sloan Kettering Cancer Center · Los Angeles, California and 2 other locations · NCT07030686

• Real-world look at SKB264 in HER2-negative breast cancer that has come back or spread

  This real-world study tests sacituzumab tirumotecan (SKB264) alone or with others in adults with recurrent or metastatic HER2-negative breast cancer.

  Recruiting at 12 sites Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Hefei, Anhui and 18 other locations · NCT06993506

• Effect of positioning after surgery on chronic subdural hematoma recurrence

  This study tests if lying in a specific position after surgery can help prevent chronic subdural hematomas from coming back in patients.

  Recruiting at 3 sites Universidad de Antioquia · Medellín, Antioquia and 2 other locations · NCT06911736

• Comparing two surgical methods for hiatal hernia repair

  This study is testing which of two surgical methods for fixing hiatal hernias works better to prevent them from coming back and improve quality of life for patients.

  Recruiting Kuopio University Hospital · Kuopio · NCT06725433

• Best drainage method after burr hole evacuation for chronic subdural hematoma

  This trial tests whether 24 hours of active subperiosteal drainage works as well as 24 hours of passive subdural drainage for adults having a single burr‑hole evacuation of a symptomatic chronic subdural hematoma.

  Recruiting at 4 sites Aalborg University Hospital · Aalborg and 3 other locations · NCT06621407

• Predicting early tumor recurrence in esophageal cancer patients

  This study is testing if certain DNA patterns from tissue samples can help predict if esophageal cancer will come back early in patients who have had surgery.

  Recruiting at 2 sites City of Hope Medical Center · Nagoya, Aichi-ken and 1 other locations · NCT06476067

• Using blood tests to guide chemotherapy in stage II colon cancer patients

  This study tests if using blood tests to check for tumor DNA can help doctors decide if stage II colon cancer patients need extra chemotherapy after surgery.

  Recruiting at 29 sites UMC Utrecht · 's-Hertogenbosch and 28 other locations · NCT06434896

• Using body posture to prevent recurrence of chronic subdural hematoma after surgery

  This study is testing if certain sleeping positions can help prevent chronic subdural hematomas from coming back after surgery.

  Recruiting Huashan Hospital · Shanghai, Shanghai Municipality · NCT06401772

• Evaluation of the Triathlon Hinge Knee System outcomes

  This study is testing how well the Triathlon Hinge Knee System works for people getting knee surgeries, looking at their recovery and safety over time.

  Recruiting at 2 sites The Cleveland Clinic · Weston, Florida and 1 other locations · NCT06379321

• Surgical treatment for gum tissue issues after removing localized growths

  This study is testing a new surgical method to help people with gum problems after removing growths, aiming to improve their gum health and reduce complications.

  Recruiting Semmelweis University · Budapest · NCT06210789

• Thyroxine therapy after thyroid surgery for low-risk cancer

  This study tests if taking thyroxine after surgery for low-risk thyroid cancer can help keep patients healthy and prevent the cancer from coming back.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06087068

• Prophylactic central neck dissection for low-risk papillary thyroid cancer

  This study is testing if a specific type of surgery can help people with low-risk thyroid cancer live longer and have fewer recurrences of the disease.

  Recruiting Phase 3 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06082180

• Neoadjuvant therapy followed by local treatment for recurrent colorectal liver metastases

  This study is testing if giving a new treatment before local therapy can help people with recurrent colorectal liver cancer live longer compared to getting local therapy right away.

  Recruiting Phase 3 Amsterdam UMC, location VUmc · Amsterdam · NCT05861505

• Using Cellvizio to assess surgical margins in Crohn's disease

  This study is testing if a special imaging tool called Cellvizio can help surgeons see hidden inflammation during surgery for Crohn's disease, so they can make better decisions about how much tissue to remove and reduce the chances of problems later on.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT05805020

• Comparing two surgical methods for Crohn's disease treatment

  This study is testing which of two surgical methods works better for treating Crohn's disease in patients needing bowel surgery to see which one leads to fewer problems after the operation.

  Recruiting Jinling Hospital, China · Nanjing, Jiangsu · NCT05658081

• Prognostic kit for early-stage lung cancer

  This study is testing a new kit to help predict the chances of lung cancer coming back in patients who have had early-stage lung adenocarcinoma surgery.

  Recruiting at 2 sites Chung Shan Medical University · Taichung, Taiwan and 1 other locations · NCT05557474

• Comparing sutures and polyglactin mesh for hiatal hernia repair

  This study is testing whether using mesh instead of just stitches during surgery can help prevent paraesophageal hernias from coming back in patients.

  Recruiting Oulu University Hospital · Oulu · NCT05201508

• Evaluating outcomes of robotic surgery for bladder cancer

  This study is testing how well robotic surgery for bladder cancer works compared to traditional surgery by looking at patients' recovery and outcomes over time.

  Recruiting University of Florence · Florence, Tuscany · NCT04900558

• Laparoscopic repair of groin hernias using a special visible mesh

  This study is testing a new type of visible mesh for fixing groin hernias to see if it works better and is safer than using glue for the procedure.

  Recruiting Algemeen Ziekenhuis Maria Middelares · Ghent · NCT02781870

NIH-funded research (newest 40 of 122)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Keloid recurrence study using multi-omics in diverse patients

  A research effort will look at why keloids come back after surgery, especially in African American patients, using comprehensive molecular data from patient samples.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11641647

• Combined Imaging and RNA Markers to Predict Head and Neck Cancer Recurrence

  A research project aims to use imaging and RNA data to better predict if head and neck cancer will come back, helping doctors tailor treatments for patients.

  NIH research Washington University · Saint Louis, United States · NIH-11607780

• Oral cancer recurrence predictor using tumor microbes and gene activity

  This NIH grant explores how bacteria and immune signals inside oral cancer tumors relate to whether the cancer comes back, with the aim of making a practical risk predictor for patients.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11591548

• How air pollution affects recurrent heart events in older adults

  This grant explores how air pollution, especially PM2.5, influences the recurrence and progression of heart problems in people aged 65 and older.

  NIH research University of Rochester · Rochester, United States · NIH-11568469

• Gene expression marks high risk for very late breast cancer return

  A patient-focused study aims to find gene patterns that identify women with early breast cancer who are most likely to have cancer come back more than a decade later.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11535236

• AI to predict melanoma coming back using tumor images, gene data, and pathology

  This project is building an AI tool that uses detailed tumor pictures, gene activity, and pathology reports to help doctors predict whether early-stage (stage I or II) melanoma might return.

  NIH research University of Chicago · Chicago, United States · NIH-11457144

• Effect of electronic cigarette vapor on ear infections and bacterial communities in kids

  A study tests how exposure to e-cigarette vapor may affect kids’ risk of ear infections and the behavior of bacteria that cause them.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11455078

• Understanding how epigenetic changes drive pediatric brain tumor recurrence and how reversing them could help

  A pediatric brain cancer research project is exploring how an epigenetic change (H3K27M) and tumor environment contribute to tumor coming back, using a reversible mouse model to study potential ways to prevent recurrence.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11453252

• Using gene expression to identify patients at high risk for late breast cancer recurrence

  Researchers are studying breast cancer patients to find gene patterns that predict who might have cancer come back many years later, so doctors can tailor care for those at highest risk.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11421472

• Gene tests to find women at high risk of breast cancer returning many years later

  This project looks for patterns in tumor gene activity to spot women with ER-positive breast cancer who are more likely to have the cancer come back more than 10 years after initial treatment.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11412218

• Local Neoadjuvant Immunotherapy to Reduce Recurrence in Oral Cancers

  A new, implantable-like hydrogel system delivers cancer-fighting drugs before surgery to help prevent head and neck cancer from coming back.

  NIH research Tiburon Bio INC. · Spring, United States · NIH-11409869

• Enhancing pre-surgery therapy to prevent breast cancer recurrence

  A new program tests ways to boost chemotherapy given before surgery to lower the chance that breast cancer comes back, especially focusing on groups that have had worse outcomes.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11389265

• Understanding why some WTC-related prostate cancers come back

  A study uses advanced tissue mapping to find why prostate cancer recurs in World Trade Center responders.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11387166

• Computational imaging and molecular data modeling to track brain tumor recurrence

  A computer-based approach uses AI and data from brain scans and molecular tests to help detect when glioblastoma may come back or change after treatment, with the goal of guiding better care.

  NIH research Old Dominion University · Norfolk, United States · NIH-11385904

• Identifying Breast Cancer Recurrence with New Data Links to a Cancer Registry

  This project uses linked health data to better identify when breast cancer comes back after treatment, helping doctors understand and care for survivors.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11385012

• Predicting 1-year death and recurrence after ischemic stroke using enriched EHR data

  Researchers are using advanced computer models to identify which stroke patients are at higher risk of dying or having another stroke within a year, by analyzing enriched electronic health records.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11381766

• How air pollution and neighborhood stress affect lung tumors in African American patients

  This project looks at whether long-term air pollution and neighborhood disadvantage change tumor DNA and short-term recurrence risk in early-stage lung cancer among African American patients.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11379068

• Supratherapeutic PTX Buttress to Reduce Recurrence After Soft Tissue Sarcoma Surgery

  A new surgical patch delivering high-dose paclitaxel directly to the tumor bed is tested to lower the chance that soft tissue sarcomas coming back after surgery.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11378590

• Keratinocytes and skin-resident T-cells: a new way to prevent HSV recurrences

  A study at Fred Hutchinson Cancer Center will explore how skin cells and resident immune cells talk to each other to prevent herpes simplex virus (HSV) from recurring in the skin.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11377482

• Quantitative imaging tool to tell tumor recurrence from radiation effects in glioblastoma

  A non-invasive MRI-based classifier helps doctors distinguish recurrent glioblastoma from treatment-related changes to spare patients unnecessary biopsy.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11377043

• FoRtitude: an online program to ease fear of cancer recurrence for breast cancer survivors

  A woman who has finished breast cancer treatment uses an online program to learn easy CBT-based steps to feel less worried about cancer coming back.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11376163

• Uncovering Why HER2+ Breast Cancer Metastasizes to the Brain

  Scientists are studying how HER2-positive breast cancer cells survive in the brain and spread, with a focus on brain metastasis and immune interactions.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11374544

• Dormant melanoma cells and aging: how the tissue environment shapes recurrence

  This NIH grant studies how aging tissue environments influence melanoma dormancy and late recurrences, with a focus on how aged lung fibroblasts and Wnt signaling affect cancer cell reawakening.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11370310

• Cell-level look at glioblastoma edges and tumors that come back

  This project uses fresh tumor slices and single-cell methods to find which cell types at the tumor core and edge respond to different drugs for people with glioblastoma.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11370167

• Predicting early peritoneal relapse in gastric cancer with AI-powered models

  A new AI-based tool will combine clinical data, CT images, and tissue slides to predict which gastric cancer patients are at risk of early peritoneal recurrence after surgery.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11367404

• Prognostic staging for recurrent breast cancer to guide care

  A Duke University-led project aims to create a prognostic classification system for women whose breast cancer has come back, so clinicians can discuss outcomes and plan treatment more clearly.

  NIH research Duke University · Durham, United States · NIH-11366240

• Why cholera came back to Haiti and how to prevent it

  Researchers are looking at cholera bacteria and environmental conditions in Haiti to find what caused the 2022 outbreak and ways to protect communities at risk.

  NIH research University of Florida · Gainesville, United States · NIH-11362322

• Predicting breast cancer recurrence and chemotherapy need using pathology images and AI

  A doctor-scientist at a major university is developing an AI-based tool that uses pathology slides to predict which breast cancer patients will benefit from chemotherapy.

  NIH research University of Chicago · Chicago, United States · NIH-11357620

• Metabolic biomarkers to diagnose and predict vaginitis caused by infection

  A new test using small molecule metabolites in vaginal fluid could quickly and cheaply tell if vaginitis is caused by BV, VVC, or trichomoniasis and help predict if it may recur.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11347160

• Proteogenomic clues to NSCLC recurrence in early-stage lung cancer

  A national study will look at the tumor’s genetic and protein signals to find clues about which early-stage non-small cell lung cancer may come back after surgery.

  NIH research Washington University · Saint Louis, United States · NIH-11345500

• Psilocybin-assisted Psychotherapy for Fear of Cancer Recurrence in Early-Stage Breast Cancer

  A study will test whether a one-time psilocybin-assisted psychotherapy session helps reduce fear of cancer returning in women with early-stage breast cancer.

  NIH research New York University School of Medicine · New York, United States · NIH-11344227

• How different macrophage types affect breast cancer spread

  Researchers are studying how two kinds of immune cells called macrophages might influence whether early breast lesions stay local or spread, with the goal of understanding which lesions could become more dangerous.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11335053

• Why Crohn's sometimes returns after surgery: genes, immunity, and gut bugs

  This project looks at how a person's genes, immune responses, and gut microbes are linked to Crohn's disease coming back after bowel surgery for people who had ileocolic resection.

  NIH research Sinai Health System · Toronto, Canada · NIH-11330272

• MRI-guided dendritic cell vaccine to prevent pancreatic cancer recurrence after surgery

  A new approach using MRI-tracked dendritic cell vaccines alongside standard therapy aims to reduce pancreatic cancer coming back after surgery.

  NIH research University of California-Irvine · Irvine, United States · NIH-11326221

• HPV genetic patterns that influence how cervical cancer responds to radiation and reveal early recurrence

  This project looks at HPV genetic patterns in people with locally advanced cervical cancer to find markers that predict how they will respond to chemoradiation and to detect recurrence earlier.

  NIH research Washington University · Saint Louis, United States · NIH-11321714

• Immune memory cells that may cause gum disease to come back

  This project looks at whether certain immune memory cells in the gums make periodontal disease return, to help people who keep getting gum disease.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11319752

• Enhanced detection of head and neck cancer recurrence using automated EV isolation and vibrational spectroscopy

  A fast-track NIH grant is funding development of an automated test using blood or saliva samples to catch head and neck cancer recurrences early.

  NIH research Illumifydx, INC. · Broomfield, United States · NIH-11315161

• Methylation test to predict melanoma recurrence after surgery

  A patient-facing test uses a DNA methylation pattern to help doctors predict if stage II melanoma might come back after surgery.

  NIH research New York University School of Medicine · New York, United States · NIH-11311446

• Smartphone early-warning system for bipolar mood episodes

  This project uses a smartphone app and algorithms to give Veterans with bipolar disorder early alerts when a mood episode may be starting.

  NIH research Minneapolis VA Medical Center · Minneapolis, United States · NIH-11310765

• Investigating how specific immune cells contribute to the recurrence of gum disease

  This study is looking at how certain immune cells in the body might be involved in the return of gum disease, using a special mouse model to see how these cells react to germs and affect gum health over time, which could help us find better ways to treat and prevent gum problems.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11310401

Related topics

Quick answers

How many Recurrence clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in China (5 trials), United States (3 trials), Netherlands (3 trials), Finland (2 trials), Japan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →