Condition

Circulating Tumor DNA clinical trials and research

• 11Clinical trials
• 17NIH research projects
• 6Countries

Newest Circulating Tumor DNA clinical trials

All recruiting trials (11)

• Using liquid biopsies and breath samples to detect lung cancer mutations

  This study is testing if using samples from blood, sputum, and breath can help find lung cancer mutations in patients with non-small cell lung cancer before and after surgery.

  Recruiting St. Joseph's Healthcare Hamilton · Hamilton, Ontario · NCT06707519

• Investigation of recurrence detection in vulva cancer patients

  This study is testing how well doctors can detect if vulva cancer comes back in women by looking at their symptoms and checking for cancer DNA in their blood over two years.

  Recruiting at 2 sites University of Aarhus · Aarhus N and 1 other locations · NCT06495554

• Using blood tests to guide chemotherapy in stage II colon cancer patients

  This study tests if using blood tests to check for tumor DNA can help doctors decide if stage II colon cancer patients need extra chemotherapy after surgery.

  Recruiting at 29 sites UMC Utrecht · 's-Hertogenbosch and 28 other locations · NCT06434896

• Exploring blood biomarkers in colorectal cancer patients after liver surgery

  This study is testing if blood samples can help predict how well colorectal cancer patients do after surgery to remove liver tumors.

  Recruiting at 13 sites GERCOR - Multidisciplinary Oncology Cooperative Group · Besançon and 15 other locations · NCT05787197

• Using circulating tumor DNA to guide treatment for advanced rectal cancer

  This study is testing if using a blood test to check for tumor DNA can help doctors give better treatment to people with advanced rectal cancer by personalizing their therapy based on their risk of recurrence.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05601505

• Understanding why some lung cancer patients don't respond to new treatments

  This study is trying to understand why some patients with advanced lung cancer don't respond to new treatments so that doctors can better tailor therapies to help them.

  Recruiting Second Xiangya Hospital of Central South University · Changsha, Hunan · NCT05598528

• Using circulating tumor DNA to guide chemotherapy for colon cancer

  This study tests if using blood samples to check for cancer DNA can help doctors decide how much chemotherapy colon cancer patients really need to improve their treatment outcomes.

  Recruiting Peking University Cancer Hospital & Institute · Beijing, Beijing Municipality · NCT05529615

• Using ctDNA to Measure Treatment Effectiveness in Ovarian Cancer

  This study is testing if measuring tumor DNA in the blood can help predict how well treatment works for people with high-grade serous ovarian cancer who are on maintenance therapy after chemotherapy.

  Recruiting Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai · NCT05027828

• Using blood tests to guide lung cancer treatment after surgery

  This study is testing if blood tests that check for tumor DNA can help doctors decide on the best follow-up treatments for people with early-stage lung cancer after surgery to lower the chance of the cancer coming back.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT04966663

• Using blood tests to analyze tumor DNA in breast and digestive cancers

  This study is testing whether blood tests that look for tumor DNA can help improve treatment and monitoring for people with breast, digestive, and gynecologic cancers.

  Recruiting Poitiers University Hospital · Poitiers · NCT04530890

• Atezolizumab and sacituzumab govitecan to prevent recurrence in triple-negative breast cancer

  This trial tests whether combining sacituzumab govitecan with atezolizumab can prevent cancer from coming back in people with triple-negative breast cancer who have residual disease after pre-surgery chemotherapy and detectable circulating tumor DNA.

  Recruiting at 4 sites Phase 2 Dana-Farber Cancer Institute · San Francisco, California and 6 other locations · NCT04434040

NIH-funded research (17)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Postoperative ctDNA in Drain Fluid to Detect Remaining Cancer in Head and Neck Cancer

  A patient-friendly test using fluid from surgical drains after head and neck cancer surgery may reveal tiny remaining cancer cells sooner.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11402625

• Prostate cancer biomarker study using tumor DNA in blood to predict treatment outcomes

  A study to see if DNA from a patient’s blood can predict how well prostate cancer treatments will work.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11398968

• Combining blood and spinal fluid DNA with protein MRI to monitor glioma therapy

  A Johns Hopkins-led study tests a noninvasive mix of tumor DNA in blood/CSF and a protein-based MRI to track how glioblastoma responds to treatment.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11364916

• Blood test to find early colorectal cancer in people under 50

  A blood test that looks for cancer-specific methylated DNA to help find colorectal cancer in people under 50.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11348782

• Using a blood test that looks for tumor DNA to monitor early and locally advanced breast cancer

  This project uses a sensitive blood test that looks for tiny bits of tumor DNA to track treatment response in people with early or locally advanced breast cancer.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11306078

• Urine-based ctDNA analysis for early cancer detection and monitoring

  A urine-based test is being developed to detect cancer DNA in urine and compare it with blood tests, with the aim of improving early detection and monitoring of cancer.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11294899

• Urine Test for Cancer DNA

  This research explores a new way to find cancer DNA in urine for people with certain types of cancer, especially those linked to HPV.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11145158

• Predicting prostate cancer treatment response using tumor DNA from blood

  This project seeks to find out if analyzing tumor DNA in blood can show which men with advanced prostate cancer will respond to androgen-targeted and PSMA-directed therapies.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11143813

• Monitoring breast cancer treatment using blood tests for tumor DNA

  This study is looking at how to better treat people with early and locally advanced breast cancer by checking for tiny bits of cancer DNA in their blood, which could help doctors spot any remaining cancer sooner and tailor treatments to each patient, reducing the chance of unnecessary therapies.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11136406

• Monitoring brain tumor treatment with blood tests and special MRI

  This research aims to find better ways to track how well glioblastoma brain tumors respond to treatment using blood tests and advanced MRI scans.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11117025

• Using blood tests to tailor treatment for lymphoma patients

  This study is looking at how a simple blood test can help doctors tailor treatment for people newly diagnosed with diffuse large B-cell lymphoma, so they can get the right amount of therapy to reduce side effects while still being effective.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11045782

• Combining blood tests and MRI to predict treatment response in early breast cancer

  This study is looking at how using blood tests to check for cancer DNA along with MRI scans can help doctors see how well early breast cancer patients are responding to their chemotherapy before surgery, so they can make better treatment decisions and improve outcomes for everyone involved.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10983795

• Using blood tests to identify prostate cancer characteristics for better treatment predictions

  This study is looking at how bits of cancer DNA found in your blood can help doctors understand your prostate cancer better and predict how well different treatments might work for you, especially when regular biopsies are tough to do.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10931638

• Finding blood markers to detect colorectal cancer in people under 50.

  This study is working on a simple blood test to help find colorectal cancer in people under 50, so that those who might be at risk can get checked out early and get the care they need.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10880613

• Using blood and MRI to monitor glioma treatment effectiveness

  This study is looking at a new way to check how well glioma treatments are working by using blood tests and special MRI scans, so patients can get quick and easy updates on their progress without needing to have surgery for tissue samples.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10878885

• Analyzing urine for cancer-related DNA

  This study is looking at whether testing urine can help detect cancer-related DNA in patients with non-metastatic HPV positive throat cancer, and it aims to see if this at-home urine test is as good as the usual blood tests and biopsies for keeping track of the disease and spotting any recurrences.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-10870078

• Improving treatment response assessment for brain cancer using MRI and blood tests

  This study is looking at how well immunotherapy and targeted therapy work for people with brain metastases by using special MRI scans and blood tests to find out if the treatment is helping or if the cancer is getting worse, all without needing any painful biopsies.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10757395

Related topics

Quick answers

How many Circulating Tumor DNA clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in China (4 trials), France (2 trials), Canada (2 trials), Denmark (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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