Condition

Ependymoma clinical trials and research

• 15Clinical trials
• 14NIH research projects
• 15Countries

Newest Ependymoma clinical trials

All recruiting trials (15)

• Intratumoral DNX-2401 for High-Grade Pediatric Brain Tumors

  This study tests whether a single injection of DNX-2401 into a pediatric brain tumor can help shrink the tumor and extend survival in kids and young adults with recurrent or refractory high-grade brain tumors.

  Recruiting Phase 2 Clinica Universidad de Navarra, Universidad de Navarra · Utrecht and 1 other locations · NCT07424092

• B7-H3 CAR T cells for recurrent brain tumors in kids and young adults

  This early-phase trial tests a personalized CAR T-cell therapy called B7-H3 CAR T for children and young adults with recurrent or progressive brain tumors.

  Recruiting at 2 sites Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07390539

• Determine the highest tolerated dose and safety of Rhenium-186 Nanoliposome in children with recurrent ependymoma or high-grade glioma

  This study tests whether 186RNL can be given safely to children and teens with recurrent ependymoma or high-grade glioma to find a safe dose for future study.

  Recruiting Phase 1 Cerenome · Chicago, Illinois · NCT07061626

• Pharmacoscopy-guided treatment for refractory brain tumors

  This trial tests whether personalized drug testing on a patient’s tumor cells can guide treatment choices for adults with hard-to-treat brain cancers like glioblastoma.

  Recruiting Phase 2 University of Zurich · Basel, Basel-Landschaft and 2 other locations · NCT06804655

• Identifying biomarkers to predict cognitive decline after radiation therapy for brain tumors

  This study is trying to find specific markers in blood and spinal fluid from young patients with brain tumors to see if they can predict problems with thinking and memory after radiation treatment.

  Recruiting Tata Memorial Centre · Mumbai, Maharashtra · NCT06779487

• Combining Lutathera® and Olaparib for treating recurrent solid tumors in children and adolescents

  This study is testing if combining Lutathera® with olaparib can help children and teenagers with hard-to-treat solid tumors that have certain receptors.

  Recruiting Phase 1/2 Fundación de investigación HM · Boadilla del Monte, Madrid · NCT06607692

• Testing PLX038 for brain and spinal cord tumors with MYC or MYCN amplifications

  This study is testing a new treatment called PLX038 for adults with brain and spinal cord tumors that have specific gene changes to see if it helps improve their condition.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06161519

• Investigating genetic and molecular profiles of pediatric brain tumors in China

  This study is trying to understand the genetic makeup of brain tumors in children to see how it affects their treatment and recovery.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT05672043

• Observational assessment of treatment outcomes for patients with primary brain tumors

  This study looks at how well treatments work for people with rare primary brain tumors using new classification guidelines to see if they help doctors group patients better.

  Recruiting at 42 sites European Organisation for Research and Treatment of Cancer - EORTC · Innsbruck and 41 other locations · NCT05259605

• Combining Ibrutinib and Indoximod for Pediatric Brain Cancer Treatment

  This study is testing a new combination of two drugs, ibrutinib and indoximod, to see if they can safely help children and young adults with hard-to-treat brain tumors feel better.

  Recruiting Phase 1 Augusta University · Augusta, Georgia · NCT05106296

• Personalized treatment for children and young adults with relapsed brain tumors

  This study is testing personalized treatment plans for children and young adults with relapsed brain tumors to see if using real-time drug screening and genetic information can help them get the best and safest therapies.

  Recruiting at 9 sites University of California, San Francisco · Los Angeles, California and 8 other locations · NCT05057702

• Proton therapy for brain tumors

  This study is testing whether proton therapy can be a better treatment option for patients with certain brain tumors by comparing it to traditional radiation methods to see if it can reduce harm to healthy tissues.

  Recruiting at 3 sites Maastricht Radiation Oncology · Maastricht, Limburg and 2 other locations · NCT04648462

• Targeted therapies for tumors from NF2-related schwannomatosis

  This platform tests several targeted drug regimens to see if they can slow or shrink progressive NF2-related tumors (vestibular and non-vestibular schwannomas, meningiomas, and ependymomas) in people with NF2-related schwannomatosis.

  Recruiting at 5 sites Phase 2 Massachusetts General Hospital · Los Angeles, California and 5 other locations · NCT04374305

• Locoregional immunotherapy using CAR T cells for pediatric brain tumors

  This study is testing a new treatment using specially modified immune cells to see if it can help children and young adults with certain types of brain tumors feel better.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT04185038

• Using advanced proton therapy to treat pediatric ependymoma

  This study is testing a new type of proton therapy for children with ependymoma to see if it safely targets tumors while protecting healthy tissue and improving their outcomes.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Boston, Massachusetts and 1 other locations · NCT03750513

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Condensates and ZFTA-driven Ependymoma in kids

  A pediatric brain tumor grant explores how ZFTA fusion proteins drive cancer by forming condensates, with the aim of finding new ways to target these tumors.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11392538

• ZFTA-RELA Ependymoma: uncovering what drives this pediatric brain cancer

  A study at St. Jude aims to understand how the ZFTA-RELA gene fusion pushes pediatric brain tumors to grow, with the goal of finding points to intervene and slow or stop cancer progression.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11377521

• Targeting EZHIP and PRC2 interaction in a pediatric brain cancer

  A cancer research grant trying to understand how a protein called EZHIP disrupts a key epigenetic regulator in a rare pediatric brain tumor to guide better treatments.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11343020

• PEP-CMV vaccine with nivolumab for pediatric and adult high-grade brain tumors

  A phase 1/2 trial tests a CMV-targeted vaccine plus a PD-1 blocker for newly diagnosed and recurrent high-grade brain tumors in children and adults.

  NIH research Washington University · Saint Louis, United States · NIH-11312693

• Understanding ZFTA-RELA Brain Cancer in Children

  This project aims to understand how a specific genetic change drives an aggressive type of children's brain cancer called ependymoma, hoping to find new ways to treat it.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11141793

• Investigating how EZHIP interacts with PRC2 in a specific brain tumor in young children

  This study is looking at how a protein called EZHIP interacts with a group of proteins that help control the growth of a specific type of brain tumor in young children, with the hope of finding new ways to treat this challenging condition.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11067759

• Investigating the role of a protein in a specific type of brain tumor.

  This study is looking at a tough type of brain tumor called ependymomas, especially in patients with a specific gene change, to see how a protein called FACT interacts with it, with the goal of finding new ways to treat these tumors better.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11058459

• New treatment for aggressive brain tumors in children and adults

  This study is testing a new treatment for kids with tough brain tumors by using a special vaccine and a medicine that helps the immune system fight the cancer better, with the hope of helping them live longer and feel better.

  NIH research Washington University · Saint Louis, United States · NIH-11029506

• Understanding how a specific gene fusion drives a type of childhood brain cancer.

  This study is looking at how a specific gene change might help cause ependymoma, a type of brain cancer in kids, and aims to find new ways to treat it by understanding how this change affects tumor growth.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-10892870

• Understanding how LDOC1 affects tumor growth in high-risk ependymoma in children

  This study is looking at how a gene called LDOC1 affects the growth of a tough brain tumor called high-risk ependymoma, which mostly affects kids, to find new ways to treat it better.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10866345

• Targeting specific cells in childhood brain tumors to improve treatment outcomes

  This study is looking at a protein called BMI1 in children with ependymoma, a type of brain tumor, to find better ways to treat this cancer and help kids have better outcomes.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10831094

• Investigating a new mechanism of cancer development in a type of brain tumor in children

  This study is looking at how specific genes might play a role in the growth of a type of brain tumor called supratentorial ependymoma in kids, with the hope of discovering new ways to treat this condition.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-10762312

• Understanding and treating a specific type of brain tumor caused by a gene fusion

  This study is looking at a specific kind of brain tumor called ependymoma, which is linked to a gene fusion, and aims to understand how this tumor grows and find new treatments that could help people with this condition.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10646671

• Understanding and treating a specific type of brain tumor caused by a gene fusion

  This study is looking at a specific kind of brain tumor called ependymoma, which is linked to a gene fusion, and aims to understand how this tumor grows and find new ways to treat it, using advanced lab techniques and models.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10603048

Related topics

Quick answers

How many Ependymoma clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (8 trials), Netherlands (3 trials), Spain (3 trials), Switzerland (2 trials), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 2: 3, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →