Supratherapeutic PTX Buttress to Reduce Recurrence After Soft Tissue Sarcoma Surgery
Official title: Supratherapeutic PTX Buttresses Reduce Locoregional Recurrence Rates Following Surgery for Soft Tissue Sarcomas
Funded at Brigham and Women's Hospital · NIH-11378590 · Data updated 2026-11-12
A new surgical patch delivering high-dose paclitaxel directly to the tumor bed is tested to lower the chance that soft tissue sarcomas coming back after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $714,326 |
| NIH project number | 5R01CA272637-05 |
| Project ID | NIH-11378590 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients undergoing surgical resection of retroperitoneal, abdominal, or pelvic soft tissue sarcomas who meet site-specific eligibility criteria.
✕Less likely to help
Patients with sarcomas outside the specified anatomical regions or those not receiving this type of surgical intervention may not benefit.
What this research studies
This project proposes a surgically implanted, high-dose chemotherapy buttress made from a polymer mesh to deliver paclitaxel right at the tumor bed after sarcoma removal. The goal is to reduce locoregional recurrence by maintaining high local drug concentrations where residual cancer cells may linger, potentially improving survival. The study will involve engineering and testing the implantable buttress and evaluating its safety and effectiveness in reducing cancer regrowth in relevant models, with a focus on perioperative use during sarcoma resections. Participants for future steps could be patients undergoing retroperitoneal, abdominal, or pelvic sarcoma surgery who meet specific criteria.
Why it matters
Potential benefit: If successful, patients could experience fewer local recurrences and potentially improved survival after sarcoma surgery.
How similar studies have gone: Previous approaches to reduce locoregional recurrence with radiotherapy or chemotherapy have had limited success, making this novel implant approach both promising and exploratory.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Raut, Chandrajit Premanand — Brigham and Women's Hospital
- Study coordinator: Raut, Chandrajit Premanand
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.