Condition

Primary Hyperparathyroidism clinical trials and research

• 12Clinical trials
• 3NIH research projects
• 6Countries

Newest Primary Hyperparathyroidism clinical trials

All recruiting trials (12)

• Role of LH and hCG in adults being evaluated for endocrine disorders

  This study looks at whether levels of luteinizing hormone (LH) and hCG in adults undergoing endocrine evaluation relate to their disease presence and outcomes.

  Recruiting Copenhagen University Hospital at Herlev · Herlev · NCT07824102

• NIRAF imaging to help parathyroid removal when preoperative tests don’t locate glands

  This trial tests whether using an NIRAF camera during parathyroid surgery helps find and remove abnormal glands in people with primary hyperparathyroidism when prior imaging hasn’t pinpointed them.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07812649

• 18F‑Fluorocholine PET/MRI and NeuroEXPLORER PET/CT to locate parathyroid tumors

  This trial will test whether 18F‑Fluorocholine PET/MRI and NeuroEXPLORER PET/CT scans can better find overactive or cancerous parathyroid glands in adults scheduled for surgery.

  Recruiting Phase 2/3 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07444723

• Amino acid transporter PET/CT imaging with MET/FET for AATS-related tumors

  This project tries PET/CT scans using 11C- or 18F-labeled MET/FET tracers to see if they better find primary or metastatic lesions in adults with amino acid transporter–related tumors such as glioma and primary hyperparathyroidism.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT07379463

• Using 18F‑choline PET/CT versus ultrasound and sestamibi to locate diseased parathyroid glands

  This trial tests whether 18F‑choline PET/CT can better locate diseased parathyroid glands than ultrasound and sestamibi scans in adults with primary hyperparathyroidism who are scheduled for surgery.

  Recruiting Region Skane · Lund · NCT07138820

• Effects of zoledronic acid before parathyroid surgery in patients with primary hyperparathyroidism

  This study tests if giving a single dose of zoledronic acid before parathyroid surgery can help improve bone health and overall well-being for people with primary hyperparathyroidism.

  Recruiting Phase 4 University of Aarhus · Aarhus N, Central Region of Denmark · NCT06859580

• Understanding genetic causes of neuroendocrine tumors in Mexican patients

  This study is trying to find out the genetic changes that cause neuroendocrine tumors in Mexican patients to help develop better treatments.

  Recruiting at 3 sites Universidad Nacional Autonoma de Mexico · Mexico City, Mexico City and 2 other locations · NCT06523582

• Understanding tumor types in patients with primary hyperparathyroidism

  This study is trying to see how often different types of tumors occur in people with primary hyperparathyroidism who are having surgery to remove their parathyroid glands.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT05997810

• Observational study on outcomes of parathyroidectomy in primary hyperparathyroidism

  This study looks at how surgery for primary hyperparathyroidism affects patients' heart, kidney, and bone health, as well as their quality of life, over several years.

  Recruiting Nantes University Hospital · Nantes, Loire-Atlantique · NCT05469087

• Observing the natural history of parathyroid disorders

  This study looks at the causes and development of parathyroid disorders, like parathyroid cancer and primary hyperparathyroidism, to see how they affect people of all ages, including during pregnancy.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04969926

• Using calcitonin to enhance SPECT-CT imaging for parathyroid adenoma localization

  This study is testing if giving calcitonin to patients with primary hyperparathyroidism before a second SPECT-CT scan can help doctors find parathyroid adenomas that were missed in the first scan.

  Recruiting Phase 4 ProMedica Health System · Toledo, Ohio · NCT03935984

• Profiling tumors in patients with parathyroid tumors

  This study is testing whether analyzing tumor and blood samples from patients with parathyroid tumors can help identify important genes for better diagnosis and treatment options.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT03039439

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating how Tau affects the parathyroid gland in older adults with hyperparathyroidism

  This study is looking at how certain proteins and vitamin D levels affect the parathyroid glands in older adults with primary hyperparathyroidism, to help us understand better how this condition can lead to problems like weak bones and a higher chance of falling.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11193152

• Understanding cognitive issues in older adults with high parathyroid hormone levels

  This study looks at how primary hyperparathyroidism might affect memory and thinking skills in older adults aged 65 and up, helping to show why it's important to diagnose and treat this condition for better brain health and overall quality of life.

  NIH research Duke University · Durham, United States · NIH-10725231

• Understanding parathyroid tumors in primary hyperparathyroidism

  This study is looking at the genes and features of parathyroid tumors in people with primary hyperparathyroidism to find clues that can help doctors tell if the problem is in one gland or multiple glands, which could lead to better, more tailored treatments for you.

  NIH research Washington University · Saint Louis, United States · NIH-10524748

Related topics

Quick answers

How many Primary Hyperparathyroidism clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (6 trials), Denmark (2 trials), Sweden (1 trial), China (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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