Profiling tumors in patients with parathyroid tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on analyzing previously collected tumor tissue and blood samples from patients with parathyroid tumors to identify differences in clinical behavior and immunohistochemical biomarkers among parathyroid carcinoma, atypical neoplasms, and adenomas. The goal is to determine potential genes that could aid in the diagnosis of these tumors. By utilizing molecular and immunohistochemical profiling, the study aims to improve diagnostic accuracy and reduce unnecessary surgical interventions. The research is conducted at the University of Texas MD Anderson Cancer Center and involves collaboration with other sites.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The patient cohort for this study consists of all patients within the prospectively maintained parathyroid database within the Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center (MDACC) or from collaborating sites, with tissue or blood available from 1968-2015, previously consented for the use of the tissue for research purposes (via Protocols LAB 08-0034, PA11-0695 and LAB03-0320 or the appropriate external mechanism for collaborating sites).
* All patients with a known diagnoses of primary hyperparathyroidism (PHPT) operated/treated in the Department of Surgical Oncology of MDACC or at a collaborating site. Patients that have provided consent for the use of the tissue or blood for research purposes will then be considered for our study (via Protocol LAB03-0320 and LAB 08-0034 or the appropriate external mechanism for collaborating sites).
* All consented patients with known diagnoses of PHPT with a histopathological diagnosis of: parathyroid carcinoma, atypical parathyroid neoplasm or parathyroid adenoma. There will be no restrictions on age, gender, or ethnicity.
* Selected patients obtained through outside collaboration who meet the selection criteria for tissue availability and diagnostic suitability for inclusion in the study.

Exclusion Criteria:

* Patients without tissue available for analysis.

Where it's running

• M D Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Nancy Perrier — M.D. Anderson Cancer Center
• Study coordinator: Nancy D. Perrier
• Email: nperrier@mdanderson.org
• Phone: 713-792-6940

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.