Investigating how Tau affects the parathyroid gland in older adults with hyperparathyroidism

Who could benefit from this research

What this research studies

This research explores the relationship between Tau protein and the effects of amyloid beta on the parathyroid gland, particularly in older adults suffering from primary hyperparathyroidism. It aims to understand how vitamin D deficiency and its receptor signaling impact calcium regulation and hormone secretion in the parathyroid glands. By examining these mechanisms, the study seeks to uncover new insights into the causes and consequences of hyperparathyroidism, which can lead to serious health issues like bone loss and increased fall risk.

Why it matters

Where this research is happening

• University of California, San Francisco
  San Francisco, United States Active

Researchers

• Principal investigator: Koh, James — University of California, San Francisco
• Study coordinator: Koh, James

Related research

Other NIH-funded projects on the same topics.

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• NIRAF imaging to help parathyroid removal when preoperative tests don’t locate glands

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• Amino acid transporter PET/CT imaging with MET/FET for AATS-related tumors

  This project tries PET/CT scans using 11C- or 18F-labeled MET/FET tracers to see if they better find primary or metastatic lesions in adults with amino acid transporter–related tumors such as glioma and primary hyperparathyroidism.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT07379463

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.