Investigating how Tau affects the parathyroid gland in older adults with hyperparathyroidism
The role of Tau in mediating the effects of abeta(1-42) on the parathyroid gland in primary hyperparathyroidism
This study is looking at how certain proteins and vitamin D levels affect the parathyroid glands in older adults with primary hyperparathyroidism, to help us understand better how this condition can lead to problems like weak bones and a higher chance of falling.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11193152 on NIH RePORTER |
What this research studies
This research explores the relationship between Tau protein and the effects of amyloid beta on the parathyroid gland, particularly in older adults suffering from primary hyperparathyroidism. It aims to understand how vitamin D deficiency and its receptor signaling impact calcium regulation and hormone secretion in the parathyroid glands. By examining these mechanisms, the study seeks to uncover new insights into the causes and consequences of hyperparathyroidism, which can lead to serious health issues like bone loss and increased fall risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals diagnosed with primary hyperparathyroidism, particularly those with low vitamin D levels.
Not a fit: Patients who are not elderly or do not have hyperparathyroidism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for hyperparathyroidism, enhancing the quality of life for older patients.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown that understanding the role of vitamin D in parathyroid function can lead to significant insights in related conditions.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Koh, James — University of California, San Francisco
- Study coordinator: Koh, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.