Condition

Gastrointestinal Stromal Tumors clinical trials and research

• 19Clinical trials
• 2NIH research projects
• 12Countries

Newest Gastrointestinal Stromal Tumors clinical trials

All recruiting trials (19)

• DCC-2618 in GIST after at least 3 prior treatments

  This trial tests whether DCC-2618 is safe in people with advanced GIST who have already tried at least three other treatments.

  Recruiting at 2 sites Phase 1 Ono Pharmaceutical Co., Ltd. · Kashiwa, Chiba and 1 other locations · NCT07618377

• Imatinib plus fampridine before surgery for KIT exon 11 gastrointestinal stromal tumor

  This trial tests whether adding fampridine to standard imatinib before surgery is safe and helps shrink KIT exon 11 mutant GIST tumors in adults.

  Recruiting Phase 1 University of California, San Diego · La Jolla, California · NCT07171203

• Testing a new drug for advanced solid tumors that express c-Kit

  This study is testing a new drug for people with advanced solid tumors that have a specific marker called c-Kit to see if it is safe and how well it works.

  Recruiting at 4 sites Phase 1 Novelty Nobility, Inc. · Ann Arbor, Michigan and 4 other locations · NCT06805825

• Understanding genetic causes of neuroendocrine tumors in Mexican patients

  This study is trying to find out the genetic changes that cause neuroendocrine tumors in Mexican patients to help develop better treatments.

  Recruiting at 3 sites Universidad Nacional Autonoma de Mexico · Mexico City, Mexico City and 2 other locations · NCT06523582

• Combining radiotherapy with ripretinib for advanced GIST treatment

  This study is testing if combining radiotherapy with ripretinib can help people with advanced GIST live longer and feel better.

  Recruiting First Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06507683

• Oral Liporaxel (paclitaxel) treatment for gastrointestinal stromal tumors

  This study will test whether taking oral Liporaxel (a form of paclitaxel) can help people with advanced GIST who stopped responding to imatinib, sunitinib, and regorafenib and whose tumors have low P‑glycoprotein levels.

  Recruiting Phase 2 Asan Medical Center · Seoul, Songpagu · NCT06326346

• Safety of laparoscopic surgery for large gastric tumors

  This study is testing whether laparoscopic surgery is safe for people with larger gastric tumors compared to those with smaller ones.

  Recruiting Fujian Medical University · Fuzhou, Fujian · NCT05938309

• Combination of rivoceranib and paclitaxel for advanced gastrointestinal stromal tumors

  This study is testing if a new combination of two drugs, rivoceranib and paclitaxel, can help adults with advanced gastrointestinal stromal tumors that haven't improved with standard treatments.

  Recruiting Phase 2 Asan Medical Center · Seoul, Seoul · NCT05905887

• Comparing Apatinib Mesylate to Standard Treatments for Advanced GIST

  This study is testing if a new drug called Apatinib Mesylate can work better than standard treatments for patients with advanced gastrointestinal stromal tumors who haven't had success with their first treatment.

  Recruiting Xiangya Hospital of Central South University · Changsha, Hunan · NCT05751733

• Temozolomide for treating SDH-deficient gastrointestinal stromal tumors

  This study is testing if a drug called temozolomide can help people with a specific type of gastrointestinal stromal tumor that doesn't respond well to standard treatments.

  Recruiting Phase 2 Asan Medical Center · Seoul, Seoul · NCT05661643

• Comparing in-person and remote monitoring for cancer follow-up

  This study is testing whether patients with rare tumors follow their post-treatment care plans better with in-person visits from a doctor or remote check-ins with a nurse.

  Recruiting Phase 2 Centre Oscar Lambret · Amiens and 2 other locations · NCT05500391

• Using imatinib to improve outcomes in gastrointestinal stromal tumors

  This study is testing if monitoring imatinib levels can help improve the quality of life for people with gastrointestinal stromal tumors while reducing side effects.

  Recruiting Phase 2 University of Kentucky · Lexington, Kentucky · NCT05493215

• Evaluating Avapritinib for Advanced Gastrointestinal Stromal Tumors

  This study is testing if Avapritinib can help people with advanced gastrointestinal stromal tumors feel better and improve their health in real-world situations.

  Recruiting First Affiliated Hospital, Sun Yat-Sen University · Guangzhou · NCT05464875

• Using Avapritinib for treating specific types of gastrointestinal stromal tumors

  This study is testing if Avapritinib can help people with hard-to-treat gastrointestinal stromal tumors that have specific gene mutations feel better and live longer.

  Recruiting First Affiliated Hospital, Sun Yat-Sen University · Guangzhou · NCT05461664

• Predicting treatment outcomes and recurrence risk in high-risk GIST patients using liquid biopsy

  This study is trying to see if analyzing blood samples for tumor DNA can help doctors predict treatment success and the chance of cancer coming back in patients with high-risk gastrointestinal stromal tumors.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT05408897

• 5 years of imatinib treatment for high-risk gastrointestinal stromal tumors

  This study is testing if taking imatinib for five years after surgery can help people with high-risk gastrointestinal stromal tumors avoid their cancer coming back.

  Recruiting Phase 2 Asan Medical Center · Seoul, Seoul · NCT05385549

• Using DNA changes to guide treatment for gastrointestinal stromal tumors

  This study is testing if changes in a specific gene can help doctors decide the best treatment for patients with gastrointestinal stromal tumors who haven't responded well to other therapies.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT05366816

• Quality assessment of sarcoma care in Europe and Latin America

  This study looks at how well patients with different types of sarcoma are treated in Europe and Latin America to see if care is better at expert centers and to find ways to improve outcomes.

  Recruiting at 7 sites Grupo Espanol de Investigacion en Sarcomas · Buenos Aires and 8 other locations · NCT04181970

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Prognostic and therapeutic roles of voltage-gated potassium channels in KIT-mutant GIST

  This grant explores how potassium channels might influence treatment response in KIT-mutant gastrointestinal stromal tumors and whether a combination therapy could improve outcomes for patients.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11345549

• Investigating how potassium channels affect treatment of certain stomach tumors

  This study is looking at a type of tumor called gastrointestinal stromal tumors (GIST) that are caused by changes in a gene, and it’s testing whether combining a cancer drug with another medication can help make the treatment more effective for patients.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11132427

Related topics

Quick answers

How many Gastrointestinal Stromal Tumors clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in China (6 trials), United States (5 trials), South Korea (4 trials), France (2 trials), Mexico (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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