Understanding tumor types in patients with primary hyperparathyroidism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine the frequency of monoclonal and polyclonal tumors in patients diagnosed with primary hyperparathyroidism who are undergoing parathyroidectomy. By comparing surgical and pathological outcomes with tumor clonal status, the study seeks to explore the relationship between tumor characteristics and multiple gland neoplasia. Participants will be recruited from four high-volume medical centers, and tumor samples will be analyzed using established genetic assays to ensure accurate clonal status determination.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Diagnosed with hyperparathyroidism (primary, secondary, or tertiary), biochemically confirmed (e.g., serum calcium and/or intact PTH consistent with the underlying etiology), and undergoing clinically indicated management
* Female and male patients
* Age ≥ 18 years
* Ability to understand and willingness to sign an IRB approved written informed consent document (or that of legally authorized representative, if applicable).

Exclusion Criteria:

* Patients with a history of cervicofacial irradiation.
* Patients currently taking lithium or with a history of lithium use.
* Pregnant patients

Where it's running

• Washington University School of Medicine
  St Louis, Missouri, United States Recruiting

Study contacts

• Study coordinator: John A Olson, MD
• Email: jaolsol@wustl.edu
• Phone: (314) 362-8020

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.