Understanding cognitive issues in older adults with high parathyroid hormone levels

Who could benefit from this research

What this research studies

This research investigates how primary hyperparathyroidism (PHPT) affects cognitive function in older adults aged 65 and above. It focuses on identifying neurocognitive symptoms, such as memory impairment and cognitive dysfunction, which may be the only signs of the condition in many patients. The study employs objective neurocognitive testing to assess the impact of PHPT on concentration and memory. By exploring these connections, the research aims to highlight the importance of diagnosing and treating PHPT to improve cognitive health and quality of life for older adults.

Why it matters

Where this research is happening

• Duke University
  Durham, United States Active

Researchers

• Principal investigator: Kazaure, Hadiza S — Duke University
• Study coordinator: Kazaure, Hadiza S

Related research

Other NIH-funded projects on the same topics.

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  This study is looking at how certain proteins and vitamin D levels affect the parathyroid glands in older adults with primary hyperparathyroidism, to help us understand better how this condition can lead to problems like weak bones and a higher chance of falling.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11193152

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  This study is looking at the genes and features of parathyroid tumors in people with primary hyperparathyroidism to find clues that can help doctors tell if the problem is in one gland or multiple glands, which could lead to better, more tailored treatments for you.

  NIH research Washington University · Saint Louis, United States · NIH-10524748

• Role of LH and hCG in adults being evaluated for endocrine disorders

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  Recruiting Copenhagen University Hospital at Herlev · Herlev · NCT07824102

• NIRAF imaging to help parathyroid removal when preoperative tests don’t locate glands

  This trial tests whether using an NIRAF camera during parathyroid surgery helps find and remove abnormal glands in people with primary hyperparathyroidism when prior imaging hasn’t pinpointed them.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07812649

• 18F‑Fluorocholine PET/MRI and NeuroEXPLORER PET/CT to locate parathyroid tumors

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  Recruiting Phase 2/3 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07444723

• Amino acid transporter PET/CT imaging with MET/FET for AATS-related tumors

  This project tries PET/CT scans using 11C- or 18F-labeled MET/FET tracers to see if they better find primary or metastatic lesions in adults with amino acid transporter–related tumors such as glioma and primary hyperparathyroidism.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT07379463

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.