Observing the natural history of parathyroid disorders
Official title: Natural History Study of Parathyroid Disorders
Run by National Institutes of Health Clinical Center (CC) · NCT04969926 · Data updated 2026-11-12
This study looks at the causes and development of parathyroid disorders, like parathyroid cancer and primary hyperparathyroidism, to see how they affect people of all ages, including during pregnancy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 6 Months to 100 Years |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Status | Recruiting |
| Started | November 30, 2021 |
| Main results expected | January 22, 2031 |
| Study ends | January 22, 2031 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT04969926 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 6 months and older who have, are suspected of having, or are related to someone with a parathyroid or related disorder.
✕Probably not a fit
Patients younger than 6 months or those with conditions that may interfere with the study objectives may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to investigate the causes and natural history of various parathyroid disorders, including parathyroid cancer and primary hyperparathyroidism. Participants, aged 6 months and older, will undergo standard care testing and provide medical history, which will be used for research purposes. The study will also explore genetic factors, biomarkers, and the evolution of these disorders over time, including their impact during pregnancy and associated health risks. Data will be collected through medical records, questionnaires, and potential biospecimen samples.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of parathyroid disorders, ultimately enhancing patient care.
How similar studies have gone: While this study focuses on the natural history of parathyroid disorders, similar observational studies have shown success in understanding other endocrine disorders.
Who can join: the full rules
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Subjects known to have, suspected of having, or at risk of developing a parathyroid or related disorder. * Age \>= 6 months. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: * Children \<= 6 months * Patients with conditions that in the opinion of the investigators can interfere with the study objectives.
Where it's running
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National Institutes of Health Clinical Center
Bethesda, Maryland, United States Recruiting
Study contacts
- Principal investigator: Smita Jha, M.D. — National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Study coordinator: Lynn M Bliss
- Email: bonemineralclinic@niddk.nih.gov
- Phone: (301) 435-7921
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Understanding genetic causes of neuroendocrine tumors in Mexican patients
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German Hypoparathyroidism Registry
This registry in Germany collects information from adults with chronic hypoparathyroidism or pseudohypoparathyroidism to better understand how the condition affects people over time and to support future research.
-
Role of LH and hCG in adults being evaluated for endocrine disorders
This study looks at whether levels of luteinizing hormone (LH) and hCG in adults undergoing endocrine evaluation relate to their disease presence and outcomes.
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NIRAF imaging to help parathyroid removal when preoperative tests don’t locate glands
This trial tests whether using an NIRAF camera during parathyroid surgery helps find and remove abnormal glands in people with primary hyperparathyroidism when prior imaging hasn’t pinpointed them.
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Amino acid transporter PET/CT imaging with MET/FET for AATS-related tumors
This project tries PET/CT scans using 11C- or 18F-labeled MET/FET tracers to see if they better find primary or metastatic lesions in adults with amino acid transporter–related tumors such as glioma and primary hyperparathyroidism.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.