Understanding parathyroid tumors in primary hyperparathyroidism
Official title: Parathyroid Tumor Clonal Status as a Biomarker in Primary Hyperparathyroidism
Funded at Washington University · NIH-10524748 · Data updated 2026-11-12
This study is looking at the genes and features of parathyroid tumors in people with primary hyperparathyroidism to find clues that can help doctors tell if the problem is in one gland or multiple glands, which could lead to better, more tailored treatments for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | December 1, 2018 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $662,448 |
| NIH project number | 7R01CA228399-05 |
| Project ID | NIH-10524748 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with primary hyperparathyroidism, particularly those experiencing symptoms related to hypercalcemia.
✕Less likely to help
Patients with primary hyperparathyroidism who are not undergoing treatment or those with other unrelated endocrine disorders may not benefit from this research.
What this research studies
This research investigates the genetic and molecular characteristics of parathyroid tumors in patients with primary hyperparathyroidism (PHPT). By analyzing tumor clonal status, the study aims to identify biomarkers that could help differentiate between single gland disease and multiple gland disease. This could lead to more personalized treatment approaches, improving patient outcomes. The research employs advanced biological assays and cell separation techniques to gather data on tumor heterogeneity.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and tailored treatments for patients with primary hyperparathyroidism.
How similar studies have gone: Previous research has shown promise in using molecular characterization to improve treatment outcomes in endocrine disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Olson, John a. — Washington University
- Study coordinator: Olson, John a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.