Understanding parathyroid tumors in primary hyperparathyroidism
Parathyroid Tumor Clonal Status as a Biomarker in Primary Hyperparathyroidism
This study is looking at the genes and features of parathyroid tumors in people with primary hyperparathyroidism to find clues that can help doctors tell if the problem is in one gland or multiple glands, which could lead to better, more tailored treatments for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10524748 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular characteristics of parathyroid tumors in patients with primary hyperparathyroidism (PHPT). By analyzing tumor clonal status, the study aims to identify biomarkers that could help differentiate between single gland disease and multiple gland disease. This could lead to more personalized treatment approaches, improving patient outcomes. The research employs advanced biological assays and cell separation techniques to gather data on tumor heterogeneity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary hyperparathyroidism, particularly those experiencing symptoms related to hypercalcemia.
Not a fit: Patients with primary hyperparathyroidism who are not undergoing treatment or those with other unrelated endocrine disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and tailored treatments for patients with primary hyperparathyroidism.
How similar studies have performed: Previous research has shown promise in using molecular characterization to improve treatment outcomes in endocrine disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Olson, John a. — Washington University
- Study coordinator: Olson, John a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.