Condition

Prematurity clinical trials and research

• 26Clinical trials
• 44NIH research projects
• 1New in 30 days
• 11Countries

Newest Prematurity clinical trials

All recruiting trials (26)

• Earlier use of an electric breast pump to maximize milk in preterm babies

  This study tests whether starting a double electric breast pump earlier (at birth) helps mothers of very preterm infants produce more milk by day 14.

  Recruiting National Maternity Hospital, Ireland · Dublin, Co. Dublin and 2 other locations · NCT07908238

• Household, wellbeing, and quality-of-life impacts of very preterm birth and necrotising enterocolitis

  This project will collect information to see if pausing or continuing milk feeds around blood transfusions relates to babies' quality of life and the financial and emotional impact on families of very preterm infants, especially those with NEC.

  Recruiting at 7 sites Imperial College London · Norwich, Norfolk and 6 other locations · NCT07192393

• Household, wellbeing, and quality-of-life impacts of very preterm birth and necrotising enterocolitis

  This project will collect information to see if pausing or continuing milk feeds around blood transfusions relates to babies' quality of life and the financial and emotional impact on families of very preterm infants, especially those with NEC.

  Recruiting at 7 sites Imperial College London · Norwich, Norfolk and 6 other locations · NCT07192393

• Adding azithromycin to ampicillin for late PPROM

  This test sees if adding a single dose of azithromycin to the usual ampicillin/amoxicillin treatment helps newborns when membranes break early between 34.0 and 36.6 weeks.

  Recruiting Phase 4 Sheba Medical Center · Ramat Gan, Israel · NCT07183462

• Medically tailored groceries to support pregnant people facing food insecurity

  This project will test whether home-delivered medically tailored groceries, with or without extra food education, help Medicaid-eligible pregnant people in Cuyahoga County improve nutrition and birth outcomes.

  Recruiting at 2 sites Case Western Reserve University · Cleveland, Ohio and 1 other locations · NCT06965530

• Tracking intellectual and motor development in babies at high risk for cerebral palsy

  This project will follow babies at higher risk for cerebral palsy to see if early thinking and movement signs predict later intellectual and motor outcomes.

  Recruiting at 3 sites University College Cork · Cork and 3 other locations · NCT06857539

• Evaluating information given to parents during prenatal consultations

  This study is trying to see if the information parents get during prenatal visits matches their experiences after their baby is born, especially regarding issues like congenital anomalies and prematurity.

  Recruiting Hospices Civils de Lyon · Bron · NCT06820892

• Changing high-flow nasal ventilation rate to see how CO2 levels respond in preterm infants

  This study will see if using a lower (2 LPM) versus higher (6 LPM) high-flow nasal ventilation rate changes carbon dioxide levels in preterm infants who need non-invasive breathing support.

  Recruiting Rambam Health Care Campus · Haifa · NCT06622902

• Giving surfactant to premature infants using a thin catheter at birth

  This study is testing if giving a special lung treatment to very premature babies right after birth using a thin tube can help them breathe better and need less breathing support in their first few days of life.

  Recruiting University College Dublin · Dublin, None Selected · NCT06557551

• Giving surfactant to premature infants using a thin catheter at birth

  This study is testing if giving a special lung treatment to very premature babies right after birth using a thin tube can help them breathe better and need less breathing support in their first few days of life.

  Recruiting University College Dublin · Dublin, None Selected · NCT06557551

• Music and parental voice to support brain and language development in very preterm infants

  This project tests whether playing music alone or music with a parent's voice in the NICU can reduce stress and support brain and language development in very preterm infants.

  Recruiting Brigham and Women's Hospital · New Haven, Connecticut and 1 other locations · NCT06536296

• Effect of human milk diets on growth in preterm infants

  This study is testing if giving moderately preterm infants more human milk can help them grow better without causing any health issues.

  Recruiting at 3 sites University of Alabama at Birmingham · Birmingham, Alabama and 3 other locations · NCT06420531

• Crawling intervention for very premature infants at risk for developmental delays

  This study is testing a new crawling method using a mini skateboard to see if it helps very premature infants improve their movement and brain development.

  Recruiting at 3 sites Centre National de la Recherche Scientifique, France · Paris and 2 other locations · NCT06027645

• Caffeine treatment for late preterm infants with breathing difficulties

  This study tests if giving caffeine to late preterm infants with breathing problems can help them breathe better and shorten their hospital stay.

  Recruiting at 2 sites Phase 2/3 Ministry of Health, Saudi Arabia · Madinah, Medina Region and 1 other locations · NCT06026163

• Different early-intervention models for premature infants using the ICF biopsychosocial approach

  This project will test whether different early-intervention approaches based on the ICF biopsychosocial model help improve neuropsychomotor development in babies born premature.

  Recruiting Federal University of Health Science of Porto Alegre · Porto Alegre, Rio Grande do Sul · NCT05989438

• Supplementing mother's milk with donor milk for preterm infants

  This study is testing if adding donor milk to the mother's milk helps very low birth weight babies grow better and stay healthier.

  Recruiting National and Kapodistrian University of Athens · Athens and 1 other locations · NCT05675397

• Exploring how maternal stress affects breastmilk and preterm infant development

  This study looks at how stress in mothers affects the quality of their breastmilk and the development of their preterm babies.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05537454

• Evaluating the effects of xylitol during pregnancy on child development

  This study is testing if taking xylitol during pregnancy helps with the brain development of children aged 4 to 8 years, comparing two different ways to measure their progress.

  Recruiting University of Washington · Lilongwe · NCT05361122

• Using Darbe and IV iron to reduce transfusions in preterm infants

  This study is testing if giving preterm infants a combination of a special medication and intravenous iron can help reduce the need for blood transfusions and support their growth and development better than regular oral iron.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT05340465

• Effects of music therapy on breathing and brain oxygen levels in premature infants

  This study tests if music therapy with ocean sounds can help improve breathing and oxygen levels in premature babies.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT05223192

• Optimizing growth and brain development in preterm infants using a robotic device

  This study is testing a special therapy bed called Calmer to see if it helps reduce stress and improve growth and brain development in preterm babies in the NICU.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT04911452

• Investigating the Role of Fatty Acids in Premature Infants' Eye Development

  This study looks at how certain fatty acids from mothers might affect the eye development of premature babies to see if they can help prevent vision problems.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT04819893

• Using wearable sensors to monitor vital signs in ICU patients

  This study is testing new wearable sensors to see if they can accurately monitor vital signs in ICU patients compared to regular monitoring devices.

  Recruiting at 2 sites Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois and 1 other locations · NCT04723654

• Effects of exclusive human milk on cardiovascular health in preterm infants

  This study tests if feeding extremely preterm infants only human milk can improve their heart health compared to those who get fortified human milk.

  Recruiting Prolacta Bioscience · Innsbruck, Tyrol · NCT04413994

• Targeted fortification of donor breast milk for preterm infants

  This study is testing if customizing the nutrients in donor breast milk helps preterm infants grow better than using regular methods.

  Recruiting Columbia University · New York, New York · NCT04294368

• Examining heart and lung health in extremely premature infants

  This study looks at the heart and lung health of extremely premature babies to see if they have problems that could affect their future health and development.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04114435

NIH-funded research (newest 40 of 44)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Butyrate-based approach to prevent vision loss in premature babies with retinopathy

  A study is exploring whether increasing butyrate levels can prevent vision-damaging retinopathy in premature infants by addressing gut bacteria and metabolic pathways.

  NIH research Meharry Medical College · Nashville, United States · NIH-11507422

• TopoROP: Multi-View Analysis to Diagnose Retinopathy of Prematurity

  A new AI-based tool analyzes retinal images to help doctors diagnose Retinopathy of Prematurity in premature babies and other patients at risk.

  NIH research Queens College · Flushing, United States · NIH-11424612

• Long-term endotypes of prematurity-related lung disease in former preemies

  A long-term study looking at why some babies born very early develop lasting breathing problems and how their genes might explain these different paths.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11404818

• Deep learning tool to diagnose retinopathy of prematurity in newborns

  A new AI-based diagnostic tool uses eye images from premature babies to help clinicians identify treatment-needed retinopathy of prematurity.

  NIH research The Trustees of the Stevens Institute of Technology · Hoboken, United States · NIH-11401397

• Cortical dystonia in kids born early

  Researchers are studying why premature birth leads to dystonia in cerebral palsy and looking for new ways to help children and adults who have this condition.

  NIH research Washington University · Saint Louis, United States · NIH-11382263

• AI-enhanced wide-field eye scans for detecting retinopathy of prematurity

  Using faster handheld wide-field eye scans plus AI to find early signs of retinopathy of prematurity in premature babies and help guide treatment.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11381770

• Retinopathy of Prematurity: Using AI to Improve How We Watch for Change in Preterm Babies' Eyes

  A Duke study is using artificial intelligence to analyze baby eye images and other retinal data to make monitoring for retinopathy of prematurity easier and less stressful for preterm infants.

  NIH research Duke University · Durham, United States · NIH-11374353

• Understanding why prematurity affects vision and how to prevent it

  Aims to understand how early eye development goes wrong in premature babies to prevent vision problems and nearsightedness.

  NIH research Oakland University · Rochester, United States · NIH-11365924

• Understanding why some prem toddler language delays occur using brain scans and talking data

  Young children born very early who are late to talk may catch up or have ongoing challenges, and this study looks at brain images and language samples to better tell the difference.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11336699

• Continuous monitor to better detect and classify apnea in premature newborns

  A small multimodal breathing monitor plus smart software designed to automatically tell what kind of apnea premature babies are having.

  NIH research Makani Science, INC. · Irvine, United States · NIH-11318949

• Using surfactant protein A to prevent eye disease in premature babies

  Researchers are exploring whether increasing surfactant protein A can protect premature babies' eyes from retinopathy of prematurity.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11314571

• Nutrition and metabolism approach to prevent eye damage in premature babies

  This project explores whether giving specific nutrients that support liver and retinal energy metabolism can help prevent or reduce eye damage in premature newborns.

  NIH research Tufts Medical Center · Boston, United States · NIH-11302698

• Investigating how bile acid receptors affect vision problems in premature infants

  This study is looking at how oxygen exposure after birth affects the eyes of premature babies with retinopathy of prematurity (ROP) and is testing a special receptor that might help protect their eyesight, with the goal of finding safer treatments to prevent serious problems.

  NIH research Meharry Medical College · Nashville, United States · NIH-11300797

• How the ROCK protein may weaken the premature baby's gut in NEC and sepsis

  This work looks at whether blocking a protein called ROCK can help protect the gut lining of premature newborns and lower their chance of necrotizing enterocolitis and newborn sepsis.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11286767

• Bedside retinal imaging to detect and track retinopathy of prematurity

  This project aims to bring easy-to-use bedside retinal imaging for premature infants to help find and track the blood vessel changes that can lead to childhood blindness.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11285192

• Placental proteins that support babies born early

  This project looks at placental proteins to find ways to help babies born before 37 weeks.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11238925

• MRI to identify causes of chronic lung disease in premature infants

  Using noninvasive MRI scans that don't need sedation or contrast to find whether the airways, lung tissue, or blood flow are the main cause of breathing problems in premature babies with chronic lung disease.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11235886

• Using bile-acid receptors to protect premature babies' vision

  Researchers are testing whether drugs that turn on the bile-acid receptor FXR can protect the retinas of premature infants at risk for retinopathy of prematurity.

  NIH research Meharry Medical College · Nashville, United States · NIH-11235852

• Investigating how short-chain fatty acids affect eye health in premature infants

  This study is looking at how a substance called butyrate, found in certain foods, might help prevent a serious eye problem in premature babies, and it aims to find a new, gentle treatment to support their eye health.

  NIH research Augusta University · Augusta, United States · NIH-11170133

• Long-term lung health after very early birth

  This project looks for genetic patterns that explain why some babies born before 28 weeks have lasting breathing problems, to help people born very prematurely.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11168722

• Using Surfactant Protein A to prevent vision loss in premature infants

  This study is looking at how a protein called Surfactant Protein A might help prevent a serious eye problem in premature babies by promoting healthy blood vessel growth in their eyes, with the goal of finding better treatments for those at risk of this condition.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11167763

• AI tool to detect retinopathy of prematurity in preterm infants

  Using artificial intelligence to help doctors spot sight-threatening retinopathy in premature babies.

  NIH research The Trustees of the Stevens Institute of Technology · Hoboken, United States · NIH-11164687

• Understanding Vision Problems in Premature Babies

  This project aims to understand why premature babies often develop vision problems and nearsightedness.

  NIH research Oakland University · Rochester, United States · NIH-11132886

• Understanding a protein called EMP2 in retinopathy of prematurity

  This work explores how a specific protein called EMP2 contributes to abnormal blood vessel growth in the eyes of premature infants with retinopathy of prematurity.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11115608

• Understanding Retinal Changes in Premature Babies to Help Their Vision

  This research aims to better understand the eye development in premature infants with retinopathy of prematurity (ROP) to help prevent vision problems later in life.

  NIH research Duke University · Durham, United States · NIH-11061265

• Understanding and treating eye problems in premature infants caused by oxygen exposure

  This study is looking at how too much oxygen can affect the eyes of premature babies and hopes to find out if certain nutrients in breast milk can help improve their eye health.

  NIH research Tufts Medical Center · Boston, United States · NIH-11050747

• A new incubator pad to help premature infants with breathing problems.

  This study is testing a new kind of pad that gently vibrates to help premature babies who have trouble breathing, with the hope of making them feel better and reducing their breathing problems.

  NIH research Prapela, INC. · Portland, UNITED STATES · NIH-11047736

• A new monitoring system for detecting breathing issues in premature babies

  This study is working on a new way to keep an eye on premature babies to better spot and understand their breathing pauses, helping doctors provide safer and better care for these little ones.

  NIH research Makani Science, INC. · Irvine, United States · NIH-11041360

• Investigating the role of placental proteins in preventing premature birth.

  This study is looking at how certain proteins from the placenta affect baby development and might cause early births, with the goal of finding ways to help prevent preterm labor and improve health for babies born too soon.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11020649

• Improving eye imaging for detecting retinopathy of prematurity in infants

  This study is working on a new handheld device that helps doctors see the tiny blood vessels in the eyes of premature babies, making it easier to spot and track retinopathy of prematurity (ROP) so they can provide better care and treatment.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11018583

• Investigating the role of Rho kinases in newborn intestinal diseases.

  This study is looking at how certain proteins affect the intestines of newborns with necrotizing enterocolitis (NEC), a serious condition, to find new ways to help protect their intestines and keep them healthy.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11013346

• Using MRI to understand lung disease in premature infants

  This study is looking to create a new way to understand chronic lung disease in premature babies, specifically bronchopulmonary dysplasia, by using advanced MRI scans that don’t require any invasive procedures, so we can find better treatments for these little ones.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10997429

• New method to predict eye problems in premature babies

  This study is looking at a gentle way to check the tiny blood vessels in the nails of premature babies to see if it can help find out which ones might be at risk for eye problems and other serious issues, so we can help them sooner and keep them healthier.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-10933417

• Using AI software to diagnose retinopathy of prematurity in infants

  This study is testing a smart computer program that helps doctors quickly and accurately check for a serious eye condition in premature babies, with the goal of preventing blindness and making sure the program works safely in real-life situations.

  NIH research Siloam Vision, INC. · Lake Oswego, United States · NIH-10931442

• Understanding vision problems and myopia in premature infants

  This study is looking at how babies born early might develop vision problems, like nearsightedness, by examining the natural activity in their eyes that helps them grow properly, with the hope of finding ways to prevent or treat these issues.

  NIH research Oakland University · Rochester, United States · NIH-10923798

• Investigating treatments for retinopathy of prematurity using VEGF and calcitriol

  This study is looking at how to better understand and treat retinopathy of prematurity (ROP) in premature babies by using special imaging techniques in mice to find safer ways to help their eyes grow healthy blood vessels.

  NIH research University of Rochester · Rochester, United States · NIH-10918271

• Investigating the effects of blood transfusions on brain development in premature infants

  This study is looking at how different blood transfusion methods might impact the brain development of premature babies, and it will follow up with those children when they turn 5 to see how they are doing in terms of thinking and behavior.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-10911140

• Investigating the effects of blood transfusions on brain development in premature infants

  This study is looking at how different blood transfusion methods might affect the brain development of premature babies, and it will check in on how these kids are doing at age five to see if there are any lasting effects on their thinking, behavior, and movement skills.

  NIH research University of Iowa · Iowa City, United States · NIH-10909876

• Using deep learning to diagnose retinopathy of prematurity

  This study is working on a new tool that uses advanced technology to help doctors quickly and accurately diagnose retinopathy of prematurity (ROP), a condition that can cause blindness in babies, making it easier for them to get the care they need.

  NIH research The Trustees of the Stevens Institute of Technology · Hoboken, United States · NIH-10872726

• Understanding vision problems in premature infants

  This study is looking to gather important information about retinopathy of prematurity (ROP) in premature babies, using advanced technology to understand how both medical and social factors can affect their vision and overall health.

  NIH research Tufts University Boston · Boston, United States · NIH-10840906

Related topics

Quick answers

How many Prematurity clinical trials are recruiting right now?

26, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (8 trials), Ireland (4 trials), France (3 trials), United Kingdom (2 trials), Israel (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 2: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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