Investigating the effects of blood transfusions on brain development in premature infants
Transfusion of Prematurity Early School Age Follow-up (TOP 5) CCC
['FUNDING_OTHER'] · UNIVERSITY OF IOWA · NIH-10909876
This study is looking at how different blood transfusion methods might affect the brain development of premature babies, and it will check in on how these kids are doing at age five to see if there are any lasting effects on their thinking, behavior, and movement skills.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10909876 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how different blood transfusion strategies impact the brain development of premature infants. By following up with children who were part of the original TOP Trial, the study aims to evaluate their neurodevelopmental outcomes at the age of five. Researchers will compare the effects of liberal versus restrictive transfusion thresholds on cognitive, behavioral, and motor skills. This approach will help identify any long-term developmental issues that may arise from the transfusion practices used in neonatal intensive care units.
Who could benefit from this research
Good fit: Ideal candidates for this research are children who were born prematurely and received red blood cell transfusions during their neonatal care.
Not a fit: Patients who were not born prematurely or did not receive blood transfusions during their neonatal care may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved transfusion practices that enhance brain development and overall outcomes for premature infants.
How similar studies have performed: Previous studies have shown varying outcomes regarding transfusion practices in neonates, but this specific follow-up on long-term neurodevelopmental effects is relatively novel.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONRAD, AMY LYNN — UNIVERSITY OF IOWA
- Study coordinator: CONRAD, AMY LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.