AI tool to detect retinopathy of prematurity in preterm infants

Deep Learning-based Diagnosis of Retinopathy of Prematurity

NIH-funded research The Trustees of the Stevens Institute of Technology · NIH-11164687

Using artificial intelligence to help doctors spot sight-threatening retinopathy in premature babies.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionThe Trustees of the Stevens Institute of Technology NIH-funded
Lab location1 site (Hoboken, United States)
Project IDNIH-11164687 on NIH RePORTER

What this research studies

As a parent of a premature infant, this project aims to create an AI that learns from retinal photos to recognize treatment-needed ROP such as plus disease. The team will expand limited training data using image-augmentation techniques and work to make images from different cameras comparable. They will train and test the model to improve consistent detection despite variable image quality. The goal is a reliable diagnostic aid that can be applied across hospitals and imaging systems.

Who could benefit from this research

Good fit: Premature infants undergoing ROP screening whose retinal images can be shared with the research team with parental consent.

Not a fit: Adults, children without ROP, or infants who do not have retinal imaging available would not directly participate or benefit from this project.

Why it matters

Potential benefit: Could enable earlier and more consistent detection of treatment-required ROP, helping reduce preventable childhood blindness.

How similar studies have performed: AI has successfully aided detection of other retinal diseases and some early ROP tools showed promise, but applying models across different cameras and small infant datasets remains a challenge.

Where this research is happening

Hoboken, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.