Investigating the role of Rho kinases in newborn intestinal diseases.
ROCK, tight junctions and prematurity in the pathogenesis of necrotizing enterocolitis and neonatal sepsis.
This study is looking at how certain proteins affect the intestines of newborns with necrotizing enterocolitis (NEC), a serious condition, to find new ways to help protect their intestines and keep them healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11013346 on NIH RePORTER |
What this research studies
This research focuses on understanding necrotizing enterocolitis (NEC), a severe condition affecting newborns that can lead to sepsis and death. The study examines how Rho-associated protein kinases (ROCK) influence the function of tight junctions in the intestines, which are crucial for maintaining a barrier against harmful bacteria. By exploring the mechanisms behind intestinal barrier injury and the regulation of cell death, the research aims to identify potential therapeutic targets to prevent or treat these life-threatening conditions in neonates.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants or newborns at risk of developing necrotizing enterocolitis or neonatal sepsis.
Not a fit: Patients who are not newborns or those who do not have risk factors for necrotizing enterocolitis or neonatal sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the incidence of necrotizing enterocolitis and neonatal sepsis, improving survival rates for newborns.
How similar studies have performed: Previous research has shown that targeting similar pathways in other conditions has led to promising therapeutic advancements, suggesting potential for success in this area as well.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Hunter, Catherine Jane — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Hunter, Catherine Jane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.