Cohort study on obesity, diabetes, and inflammation across different ethnicities

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to recruit 350 participants aged 18-75 from various ethnic backgrounds to investigate the relationship between obesity, diabetes, and inflammation. Participants will provide data and biological samples, including blood, stool, and adipose tissue, to better understand the impact of ethnicity and body mass index on diabetes risk. The study focuses on individuals with stable weight, including those scheduled for bariatric or abdominal surgery, to gather comprehensive insights into these interconnected health issues.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants will be healthy individuals between the ages of 18-75 years. These cutoffs are designed to allow inclusion of postmenopausal women, and younger/more active patients who are increasingly undergoing bariatric surgery.
* Patients with either diabetes type 2 or the metabolic syndrome will be included in the cohort.

Exclusion Criteria:

* Participants with chronic kidney disease (\> stage 4)
* Autoimmune/inflammatory disease (e.g., Lupus, Ulcerative Colitis, etc.)
* Unstable angina, New York (NY) class III or IV congestive heart failure or myocardial infarction within 3 months of entry
* Clinically significant liver disease (e.g. Cirrhosis or liver failure)
* Weight \> 450 pounds (DXA scan weight limit)
* History of organ transplant
* Treatment with chemotherapy or radiation therapy at the time of enrollment in study.
* Poorly controlled asthma (participants requiring inhaled glucocorticoids and/or oral glucocorticoids)
* Current nasal corticosteroid use (within the past month)
* Excessive alcohol or substance abuse
* Current use of anabolic steroids or testosterone for bodybuilding purposes. Testosterone use is permitted if prescribed for hypogonadism and dose stable for the past 6 months.
* Patients actively enrolled in interventional trials involving investigational agents
* Pregnant or breast-feeding women
* Appears unlikely or unable to participate in the required study procedures as assessed by the investigator, study coordinator or designee.
* History of abnormal clotting
* Previous bariatric surgery
* Anticoagulant use
* Methadone medication

Where it's running

• University of California San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Suneil Koliwad, MD,PhD — University of California, San Francisco

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.