Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of mirabegron, a ß3 agonist, on glucose metabolism in obese, insulin-resistant individuals with prediabetes. Participants will receive either mirabegron, tadalafil, a combination of both, or a placebo over a 14-week period. The goal is to determine if these treatments can improve glucose homeostasis and potentially reverse prediabetes. The study will comprehensively analyze changes in glucose tolerance among the different treatment groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hemoglobin A1C between 5.7 and 6.4
* Body mass index between 27 and 45

Exclusion Criteria:

* Diabetes
* Chronic use of any antidiabetic medications
* Any unstable medical condition
* Use of steroids or daily use of NSAIDS
* History of chronic inflammatory conditions
* Use of anticoagulants
* Contraindications to the use of mirabegron or tadalafil
* Any condition deemed risky by the study physician

Where it's running

• University of Kentucky
  Lexington, Kentucky, United States Recruiting

Study contacts

• Principal investigator: Philip Kern, M.D. — University of Kentucky
• Study coordinator: Zach Leicht
• Email: zachary.leicht@uky.edu
• Phone: 859-218-1397

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.