Condition

Osteomyelitis clinical trials and research

• 10Clinical trials
• 15NIH research projects
• 11Countries

Newest Osteomyelitis clinical trials

All recruiting trials (10)

• Population pharmacokinetics of rifampicin in staphylococcal osteoarticular infections

  This study tests how rifampicin behaves in the body of adults with staphylococcal osteoarticular infections when given with levofloxacin or ciprofloxacin, to see how drug exposure relates to tolerance and outcomes.

  Recruiting Groupe Hospitalier Diaconesses Croix Saint-Simon · Paris, Paris · NCT07788404

• Genex with gentamicin for treating osteomyelitis of the arms and legs

  This trial tests whether Genex with gentamicin, an antibiotic-loaded bone void filler, can help adults with chronic osteomyelitis of the arms or legs when used during surgical treatment.

  Recruiting at 3 sites Biocomposites Ltd · San Diego, California and 3 other locations · NCT07270380

• Cerament G in partial calcanectomy for heel bone infection

  This trial tests whether adding Cerament G to partial calcanectomy helps heal wounds and lower reinfection in adults with calcaneal osteomyelitis.

  Recruiting Royal College of Surgeons, Ireland · Galway · NCT07057817

• Single antibiotic versus two antibiotics for Pseudomonas bone infection

  This study will test whether one antibiotic works as well as two for adults with bone infections caused by Pseudomonas aeruginosa.

  Recruiting Centre Hospitalier de Saint-Denis · Saint-Denis, France · NCT07056881

• Using CERAMENT G during single-stage surgery to treat chronic osteomyelitis

  This test uses CERAMENT G to fill bone defects during a single-stage operation for people with chronic, severe osteomyelitis to help bone heal and lower the risk of reinfection.

  Recruiting Bonesupport Ab · Oxford · NCT06555848

• Comparing STIMULAN VG to standard care for treating severe pressure ulcers with infection

  This study is testing if a new treatment called STIMULAN VG, used with surgery and antibiotics, can help adults with severe pressure ulcers and infections heal better than standard care alone.

  Recruiting at 9 sites Phase 2 Biocomposites Ltd · Phoenix, Arizona and 8 other locations · NCT06283979

• Surgical and antibiotic treatment for pressure ulcers linked to osteomyelitis

  This study is testing if a combined surgery and antibiotic treatment can help people with neuromotor disabilities who have pressure ulcers linked to bone infections heal better.

  Recruiting Institut de Sante Parasport Connecte Synergies · Garches · NCT05713149

• Oral antibiotics for treating bone and joint infections in children

  This study tests if giving only oral antibiotics can effectively treat bone and joint infections in children, compared to the usual method that starts with IV antibiotics.

  Recruiting at 9 sites Phase 4 Murdoch Childrens Research Institute · Kingswood, New South Wales and 10 other locations · NCT04538053

• Using hyperbaric oxygen therapy after lower limb amputation

  This study is testing if adding hyperbaric oxygen therapy after a leg amputation can help patients heal better and reduce the chances of needing more amputations.

  Recruiting at 2 sites Oslo University Hospital · Oslo and 1 other locations · NCT03594344

• Using fosfomycin to treat severely infected patients

  This study is testing if an intravenous antibiotic called fosfomycin can safely help people with serious infections like osteomyelitis and bacterial meningitis feel better.

  Recruiting at 45 sites Infectopharm Arzneimittel GmbH · Hall in Tirol and 49 other locations · NCT02979951

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Chronic nonbacterial bone disease in kids: analyzing real-world data across many clinics

  This grant uses patient data from many centers to understand how well current treatments work for chronic nonbacterial osteomyelitis in children and young adults.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11494236

• Understanding the protective and susceptible immune pieces of Staphylococcus aureus bone infection

  Researchers are studying how the immune system responds to Staphylococcus aureus bone infections to find ways to improve prevention and treatment for patients.

  NIH research University of Rochester · Rochester, United States · NIH-11384676

• Understanding why antibiotics sometimes fail to cure bone infections like osteomyelitis

  This grant studies why some bone infections keep coming back even with strong antibiotics, with the goal of making treatments work better for people with osteomyelitis.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11372817

• Immunotherapy for Osteomyelitis: a new IL-2 based treatment

  A new treatment approach is being explored to help bone infections like osteomyelitis by using a specialized immune-boosting agent to enhance the body’s own defense against bacteria.

  NIH research Celdara Medical, LLC · Lebanon, United States · NIH-11312523

• Fluoromannitol PET imaging to find bone infections in sickle cell disease

  This work uses a new PET tracer called fluoromannitol to help doctors tell whether bone pain in people with sickle cell disease is caused by infection or by a pain crisis.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11292433

• Host factors that drive persistent Staphylococcus aureus bone infection after implants

  This grant studies why Staphylococcus aureus sticks around in bone after implants and how the body’s immune cells respond, with the goal of guiding better treatments.

  NIH research University of Rochester · Rochester, United States · NIH-11273538

• Immune proteins that protect or raise risk in Staph bone infections

  This project looks at which antibodies and immune cells help people recover from Staphylococcus aureus bone infections and whether a new mRNA vaccine approach can change who is protected.

  NIH research University of Rochester · Rochester, United States · NIH-11178455

• Comparing treatments for children with Chronic Nonbacterial Osteomyelitis

  This study is looking at how well different treatments work for kids and young adults with Chronic Nonbacterial Osteomyelitis (CNO) to find out which ones help them feel better and live happier lives.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11175002

• Staph bone infections and the bacterial enzymes that make them worse

  This research looks at how enzymes made by Staphylococcus aureus change bone infections and whether targeting those enzymes could help people with osteomyelitis.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11169771

• How immune signals cause Staph aureus bone infections and damage

  The team is comparing how different immune pathways cause bone damage during Staphylococcus aureus infections to help people with osteomyelitis.

  NIH research Washington University · Saint Louis, United States · NIH-11158651

• Understanding why antibiotics sometimes fail for bone infections

  This research explores why antibiotics don't always work for serious bone infections, aiming to find better ways to treat them.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11111441

• New imaging agent to identify bone infections in sickle cell disease

  This study is testing a new imaging tool to help doctors better spot a serious bone infection called osteomyelitis in people with sickle cell disease, using mice to see how well it works before it’s used in patients.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11108961

• Understanding how S. aureus causes bone infections

  This study looks at how a type of bacteria called Staphylococcus aureus causes a painful bone infection known as osteomyelitis, and it aims to understand how our immune system reacts to these infections in the bones, especially when the bacteria are hard to treat with antibiotics.

  NIH research Washington University · Saint Louis, United States · NIH-10899448

• Understanding bone damage and inflammation in SAPHO syndrome and chronic nonbacterial osteomyelitis

  This study is looking at SAPHO syndrome and chronic nonbacterial osteomyelitis, which cause pain in bones and joints, to better understand how these conditions affect people and what might make them worse, so we can find better ways to help those who are dealing with these issues.

  NIH research University of Iowa · Iowa City, United States · NIH-10897975

• Understanding why antibiotics fail to treat bone infections

  This study is looking into why antibiotics sometimes don't work for people with osteomyelitis, a tough bone infection, so we can find better ways to treat it and help patients heal.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10877937

Related topics

Quick answers

How many Osteomyelitis clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in France (3 trials), United Kingdom (2 trials), Ireland (2 trials), United States (2 trials), Austria (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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