Immunotherapy for Osteomyelitis: a new IL-2 based treatment
Official title: Development of an immunotherapeutic agent for treatment of osteomyelitis
Funded at Celdara Medical, LLC · NIH-11312523 · Data updated 2026-11-12
A new treatment approach is being explored to help bone infections like osteomyelitis by using a specialized immune-boosting agent to enhance the body’s own defense against bacteria.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Celdara Medical, LLC NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project start | August 21, 2026 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $320,863 |
| NIH project number | 1R43AI192073-01A1 |
| Project ID | NIH-11312523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with osteomyelitis or those at risk due to bone infection, prior surgery, or diabetes complications.
✕Less likely to help
People without bone infections or immune-related conditions may not benefit from this therapy.
What this research studies
This early-stage grant plans to develop CM-HZ01, an IL-2 based therapy, and test its production and ability to expand the body's powerful immune cells to fight bone infections. The work focuses on making the therapy reliably and safely so that cytotoxic CD8 T-cells and NK cells can better attack bacteria such as Staphylococcus aureus in bone tissue. By improving immune responses, the project aims to reduce infection duration and complications in patients, including those with diabetes who are at higher risk. The proposed studies are designed to move from production toward demonstrating immune cell expansion in a controlled setting before human trials.
Why it matters
Potential benefit: If successful, the therapy could strengthen the body's immune response to bone infections and potentially shorten treatment times.
How similar studies have gone: IL-2 based therapies have shown immune activation in other settings, but the specific high-avidity IL-2 approach for osteomyelitis is exploratory and early-stage.
Where this research is happening
-
Celdara Medical, LLC
Lebanon, United States Active
Researchers
- Principal investigator: Mack, Stephanie — Celdara Medical, LLC
- Study coordinator: Mack, Stephanie
Related research
Other NIH-funded projects on the same topics.
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Understanding why antibiotics sometimes fail to cure bone infections like osteomyelitis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.