New imaging agent to identify bone infections in sickle cell disease
[18F]fluoromannitol: A novel imaging agent to delineate osteomyelitis in sickle cell disease
This study is testing a new imaging tool to help doctors better spot a serious bone infection called osteomyelitis in people with sickle cell disease, using mice to see how well it works before it’s used in patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11108961 on NIH RePORTER |
What this research studies
This research focuses on developing a novel imaging agent, [18F]fluoromannitol, to help diagnose osteomyelitis in patients with sickle cell disease (SCD). Osteomyelitis is a serious bacterial infection that can be difficult to differentiate from other complications of SCD. The study aims to create a reliable positron emission tomography (PET) imaging method that can specifically identify this infection, which is crucial for timely and effective treatment. By using a mouse model, the researchers will validate the effectiveness of this imaging agent in detecting bacterial infections associated with SCD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with sickle cell disease who are at risk for developing osteomyelitis.
Not a fit: Patients without sickle cell disease or those who do not have a risk of osteomyelitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment of osteomyelitis in patients with sickle cell disease, potentially reducing severe health outcomes.
How similar studies have performed: Other research has shown promise in using novel imaging agents for diagnosing infections, suggesting potential success for this approach.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Neumann, Kiel — St. Jude Children's Research Hospital
- Study coordinator: Neumann, Kiel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.