Single antibiotic versus two antibiotics for Pseudomonas bone infection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will follow 300 adults with culture-confirmed Pseudomonas aeruginosa osteomyelitis and compare outcomes between those treated with monotherapy and those given combination antibiotic therapy. Clinical data, imaging results, microbiology reports, surgical interventions, adverse events, and total antibiotic exposure will be recorded. Primary comparisons include treatment success, need for additional surgery, emergence of antibiotic resistance, adverse effects, and overall antibiotic use. Analyses will adjust for baseline differences between groups using standard clinical definitions for cure and failure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years old)
* Diagnosis of osteitis or osteomyelitis due to Pseudomonas aeruginosa
* Isolation of Pseudomonas aeruginosa from at least one deep, sterile sample (e.g., bone biopsy, joint aspiration)
* Imaging findings consistent with osteomyelitis (MRI, CT scan, or X-ray)

Exclusion Criteria:

* No isolation of Pseudomonas aeruginosa
* No imaging evidence suggestive of osteomyelitis
* Patients under 18 years of age

Where it's running

• Centre Hospitalier de Saint-Denis
  Saint-Denis, France, France Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.