Understanding bone damage and inflammation in SAPHO syndrome and chronic nonbacterial osteomyelitis
Official title: Investigating Disease Activity, Bone Damage and Interleukin-1 Genes in Adult SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis
Funded at University of Iowa · NIH-10897975 · Data updated 2026-11-12
This study is looking at SAPHO syndrome and chronic nonbacterial osteomyelitis, which cause pain in bones and joints, to better understand how these conditions affect people and what might make them worse, so we can find better ways to help those who are dealing with these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $167,400 |
| NIH project number | 5K23AR082966-02 |
| Project ID | NIH-10897975 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with SAPHO syndrome or chronic nonbacterial osteomyelitis.
✕Less likely to help
Patients with other inflammatory or autoimmune conditions unrelated to SAPHO syndrome or chronic nonbacterial osteomyelitis may not benefit from this research.
What this research studies
This research investigates SAPHO syndrome and chronic nonbacterial osteomyelitis, which are painful conditions affecting bones and joints. The study aims to assess disease activity through clinician evaluations, patient reports, and MRI scans in a large group of adult patients. It will also identify risk factors that contribute to bone damage and explore genetic variants in the interleukin-1 pathway that may influence the disease's clinical features. By addressing these critical knowledge gaps, the research seeks to improve understanding and management of these debilitating conditions.
Why it matters
Potential benefit: If successful, this research could lead to better assessments and potential future therapies for patients suffering from SAPHO syndrome and chronic nonbacterial osteomyelitis.
How similar studies have gone: While research on SAPHO syndrome is limited, similar studies on autoinflammatory diseases have shown promise in understanding disease mechanisms and improving patient outcomes.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Lenert, Aleksander — University of Iowa
- Study coordinator: Lenert, Aleksander
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.