Comparing treatments for children with Chronic Nonbacterial Osteomyelitis
Official title: Comparative effectiveness study of current treatments in children with Chronic Nonbacterial Osteomyelitis (CNO)
Funded at Seattle Children's Hospital · NIH-11175002 · Data updated 2026-11-12
This study is looking at how well different treatments work for kids and young adults with Chronic Nonbacterial Osteomyelitis (CNO) to find out which ones help them feel better and live happier lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 16, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $408,031 |
| NIH project number | 1R56AR083929-01 |
| Project ID | NIH-11175002 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults diagnosed with Chronic Nonbacterial Osteomyelitis who have not responded adequately to first-line treatments.
✕Less likely to help
Patients with other underlying conditions that complicate the treatment of CNO may not benefit from this research.
What this research studies
This research investigates the effectiveness of various treatments for Chronic Nonbacterial Osteomyelitis (CNO) in children and young adults. It aims to compare first-line treatments, such as non-steroidal anti-inflammatory drugs (NSAIDs), with second-line therapies like disease-modifying anti-rheumatic drugs (DMARDs) and bisphosphonates. By analyzing data from a large patient registry, the study seeks to determine the best treatment options to improve patient outcomes and quality of life. Patients will be monitored for their response to these treatments over time.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for children suffering from CNO, potentially improving their quality of life.
How similar studies have gone: Previous research has shown promising results in evaluating treatment effectiveness for similar autoinflammatory conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Zhao, Yongdong — Seattle Children's Hospital
- Study coordinator: Zhao, Yongdong
Related research
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This grant uses patient data from many centers to understand how well current treatments work for chronic nonbacterial osteomyelitis in children and young adults.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.