Effects of mTOR Inhibition on Muscle Health in Older Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of inhibiting the mechanistic target of rapamycin (mTOR) on muscle health in older adults experiencing muscle atrophy and age-related sarcopenia. Participants will undergo unilateral resistance exercise training while receiving Rapamune (sirolimus) to assess its impact on muscle protein synthesis and overall muscle function. The study aims to explore whether mTOR inhibition can enhance muscle responses to exercise in individuals who may not be able to engage in regular physical activity. By understanding the role of mTOR in muscle maintenance, the research seeks to identify potential therapeutic strategies for combating age-related muscle loss.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study
* Participant is physically able to complete the resistance exercise training programme

Exclusion Criteria:

* • A BMI \<18 or \>35 kg/m2

  * Active cardiovascular, cerebrovascular or respiratory disease: e.g. uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD, pulmonary hypertension or recent stroke
  * Any metabolic disease
  * Clotting dysfunction
  * A history of, or current neurological or musculoskeletal conditions (e.g. epilepsy)
  * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (this must remain for ALL UoN FMHS UREC approved studies)
  * Contraindications to MRI scanning including claustrophobia, pacemaker, metal implants etc. which will be assessed through an MRI safety screening questionnaire.
  * Contraindications to the use of Rapamycin e.g. those due scheduled vaccinations (as rapamycin can reduce the efficacy of vaccines).

Where it's running

• University of Nottingham School of Medicine
  Derby, United Kingdom Recruiting

Study contacts

• Study coordinator: Philip Atherton, PhD
• Email: philip.atherton@nottingham.ac.uk
• Phone: 01332724725

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.