Investigating how MuRF1 affects muscle loss
Official title: MuRF1 substrates and mechanisms of skeletal muscle atrophy
Funded at Oklahoma Medical Research Foundation · NIH-11061929 · Data updated 2026-11-12
This study is looking at a protein called MuRF1 that is connected to muscle loss, and by figuring out how it works with other proteins in muscle, the researchers hope to find new ways to create treatments that can help people keep their muscles strong and healthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $181,924 |
| NIH project number | 5R21AR084235-02 |
| Project ID | NIH-11061929 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing muscle atrophy due to conditions such as cancer, cardiovascular diseases, or aging.
✕Less likely to help
Patients with muscle atrophy not linked to MuRF1 or those with unrelated muscle disorders may not benefit from this research.
What this research studies
This research focuses on understanding the role of MuRF1, a protein linked to muscle atrophy, in various diseases. By studying how MuRF1 interacts with other proteins in muscle tissue, the researchers aim to identify new targets for drug development that could help prevent or treat muscle loss. The approach involves advanced techniques like mass spectrometry to analyze protein modifications in muscle samples. Patients may benefit from insights that could lead to effective therapies for conditions causing muscle wasting.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse muscle atrophy in patients suffering from various diseases.
How similar studies have gone: Previous research has shown promising results in targeting E3 ligases for muscle atrophy, suggesting that this approach could be effective.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Bodine, Sue C — Oklahoma Medical Research Foundation
- Study coordinator: Bodine, Sue C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.