Investigating how age-related muscle loss is influenced by specific molecules
LOOH-induced muscle atrophy with age
['FUNDING_R01'] · UNIVERSITY OF UTAH · NIH-10987032
This study is looking at how getting older can cause muscle loss, which can make it harder to move and lead to other health problems, and it will test new treatments that might help protect muscle in older adults by targeting harmful molecules in the body.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-10987032 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how aging leads to muscle loss, known as sarcopenia, which affects mobility and increases the risk of other health issues. The study will explore the role of reactive oxygen species, particularly lipid peroxides, in promoting muscle atrophy through specific cellular processes. By testing treatments that neutralize these harmful molecules, the researchers aim to find potential therapies to prevent muscle loss in older adults. Patients may be involved in trials assessing the effectiveness of these treatments in preserving muscle mass.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing muscle loss or sarcopenia.
Not a fit: Patients who are not experiencing muscle loss or are younger than the targeted age group may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help maintain muscle mass in older adults, improving their mobility and overall quality of life.
How similar studies have performed: Previous research has shown promising results in targeting oxidative stress to mitigate muscle atrophy, suggesting that this approach may be effective.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FUNAI, KATSUHIKO — UNIVERSITY OF UTAH
- Study coordinator: FUNAI, KATSUHIKO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.