Investigating how age-related muscle loss is influenced by specific molecules
Official title: LOOH-induced muscle atrophy with age
Funded at University of Utah · NIH-10987032 · Data updated 2026-11-12
This study is looking at how getting older can cause muscle loss, which can make it harder to move and lead to other health problems, and it will test new treatments that might help protect muscle in older adults by targeting harmful molecules in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | February 1, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $478,750 |
| NIH project number | 5R01AG074535-04 |
| Project ID | NIH-10987032 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing muscle loss or sarcopenia.
✕Less likely to help
Patients who are not experiencing muscle loss or are younger than the targeted age group may not benefit from this research.
What this research studies
This research focuses on understanding how aging leads to muscle loss, known as sarcopenia, which affects mobility and increases the risk of other health issues. The study will explore the role of reactive oxygen species, particularly lipid peroxides, in promoting muscle atrophy through specific cellular processes. By testing treatments that neutralize these harmful molecules, the researchers aim to find potential therapies to prevent muscle loss in older adults. Patients may be involved in trials assessing the effectiveness of these treatments in preserving muscle mass.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help maintain muscle mass in older adults, improving their mobility and overall quality of life.
How similar studies have gone: Previous research has shown promising results in targeting oxidative stress to mitigate muscle atrophy, suggesting that this approach may be effective.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Funai, Katsuhiko — University of Utah
- Study coordinator: Funai, Katsuhiko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.