Using electrical stimulation and high protein diet to aid recovery after brain hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of early neuromuscular electrical stimulation (NMES) and high protein supplementation (HPRO) on recovery in adults diagnosed with subarachnoid hemorrhage (SAH). Participants will be divided into two groups: one receiving NMES and HPRO, and the other receiving standard care. The study aims to assess improvements in muscle mass, metabolic and inflammatory biomarkers, and motor strength. By comparing these outcomes, the researchers hope to establish a more effective recovery protocol for SAH patients.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. . Being diagnosed with aneurysmal SAH
2. . Aneurysmal repair within 48 hours of ictus.
3. . Age between 25 and 80 years old. (\>=25 years old and \<=80 years old)
4. . Expected stay in the NCCU \> 72 hours.
5. . Admission Hunt Hess Grade \>=2.
6. modified Fisher score \>1.

Exclusion criteria:

1. . Subjects diagnosed with SAH from trauma, rupture of an arteriovenous malformation, neoplasm, vasculitis, or other secondary causes;
2. . Unlikely to survive one week post hemorrhage either due to impending brain death or likely request for withdrawal of care;
3. . Unlikely to remain in the ICU for more than 7 days;
4. . Body mass index \< 15 or \>40 kg/m2;
5. . Allergy to whey protein;
6. . Evidence of lower extremity paresis or spasticity within 48 hours of injury
7. . Pre-morbid modified Rankin Score \>1.
8. . Known pregnancy
9. . Presence of active malignancy
10. . Diagnosis of an inflammatory disorder
11. . Presence of a neuromuscular disorder
12. . Diagnosis of chronic renal insufficiency or acute kidney injury (GFR \< 30 mL/min/1.73m2)
13. . Hepatic insufficiency defined as AST/ALT levels \>2.5 above normal upper limits.
14. . On-going seizure activity as assessed clinically or by electrographic detection on continuous electroencephalogram (cEEG) at time of enrollment
15. . Prisoner.

Where it's running

• University of Maryland Medical Center
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Neeraj Badjatia, MD MSc — University of Maryland, Baltimore
• Study coordinator: Neeraj Badjatia, MD MSc
• Email: nbadjatia@umm.edu
• Phone: 4103284515

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.