Investigating how UBR5 affects muscle loss and recovery
The role of UBR5 in skeletal muscle atrophy and regrowth
This study is looking at a protein called UBR5 to see how it affects muscle loss and recovery, which could help people who are dealing with muscle weakness from long-term illnesses or not using their muscles enough.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10868891 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein, UBR5, in the processes of muscle atrophy and regrowth. By studying how UBR5 influences protein turnover, the research aims to uncover mechanisms that contribute to muscle health, especially in individuals experiencing muscle loss due to chronic diseases or disuse. The approach involves using animal models to manipulate UBR5 levels and observe the resulting effects on muscle mass and recovery. This could lead to new insights into treatments that enhance muscle maintenance and growth.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing muscle atrophy due to chronic diseases or disuse.
Not a fit: Patients who do not have issues related to muscle atrophy or who are not affected by chronic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help prevent or reverse muscle loss in patients with chronic illnesses.
How similar studies have performed: Other research has shown promising results in understanding the role of E3 ubiquitin ligases in muscle health, suggesting that this approach could yield valuable insights.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Hughes, David C — Oklahoma Medical Research Foundation
- Study coordinator: Hughes, David C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.