Condition

Major Depressive Disorder (MDD) clinical trials and research

• 78Clinical trials
• 1NIH research projects
• 5New in 30 days
• 26Countries

Newest Major Depressive Disorder (MDD) clinical trials

All recruiting trials (78)

• Emotional Reactivity in Severe Alcohol Use Disorder and Depression Using Eye-Tracking and Physiological Measures

  This study tests how people with severe alcohol use disorder, major depressive disorder, both conditions, or neither, recognize and react to emotions using eye-tracking and physiological data.

  Recruiting Université Catholique de Louvain · Brussels, Belgium · NCT07925281

• Temporally Interfering Electrical Stimulation for Major Depressive Disorder

  This study tests whether noninvasive temporally interfering electrical stimulation can help people with major depressive disorder.

  Recruiting at 2 sites Tianjin Medical University General Hospital · Fuzhou, Fujian and 1 other locations · NCT07924917

• Affective Cognitive Training for mood disorders and their close relatives

  A six-week program combining virtual reality and computer exercises tests whether affective cognitive training helps people with mood disorders and their unaffected first-degree relatives.

  Recruiting Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital · Frederiksberg, Capital Region of Denmark · NCT07920302

• ALKS 7290 added to antidepressants for adults with major depression

  This study tests whether ALKS 7290, taken with current antidepressants, helps adults with major depressive disorder.

  Recruiting Phase 2 Alkermes, Inc. · Jacksonville, Florida · NCT07901179

• French Minds: a French, Multimodal Cohort Study of Severe Psychiatric Disorders and Healthy Controls

  This study tests whether people with mood, psychotic, or autism disorders can be grouped into more similar subtypes based on social withdrawal and anhedonia, across ages 15 to 60.

  Recruiting at 10 sites Fondation FondaMental · Besançon and 16 other locations · NCT07881016

• EEG-Guided TMS for Adults With Depression

  This study tests whether delivering intermittent theta burst stimulation (iTBS) timed to brain waves using EEG can improve treatment for adults with major depressive disorder who have not responded to usual antidepressants.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07862205

• Add-on anti-inflammatory therapy for adults with depression and high inflammation

  This study tests whether adalimumab, given with your regular antidepressant Lexapro, can improve depressive symptoms in adults with major depressive disorder and high inflammation.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07845604

• Ketamine plus behavioral activation therapy for treatment-resistant depression

  This study tests whether adding behavioral activation therapy to ketamine treatment helps adults with treatment-resistant depression feel better than ketamine alone.

  Recruiting Phase 2/3 The Royal's Institute of Mental Health Research · Ottawa, Ontario · NCT07801703

• EEG microstates and inflammatory markers in treatment-resistant depression patients undergoing ECT

  This study tests how electroconvulsive therapy affects brain activity patterns seen in EEG and inflammatory biomarkers in adults with treatment-resistant major depression.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Bakırköy · NCT07748091

• Cannabidiol Oil as an Add-on for Treatment-Resistant Major Depression

  This study tests whether full-spectrum CBD oil added to standard antidepressants can help adults with treatment-resistant major depression.

  Recruiting Phase 1/2 Universidade do Sul de Santa Catarina · Tubarão, Santa Catarina · NCT07696871

• VTA real-time biofeedback with 7-Tesla MRI in depression

  This study tests whether people with major depressive disorder can learn to modulate their brain's reward center (the VTA) using real-time feedback during 7-Tesla MRI sessions, to see if it changes mood and motivation.

  Recruiting University of Oxford · Oxford · NCT07694076

• Faster brain stimulation for PTSD and depression

  This pilot study tests a quicker brain stimulation schedule (accelerated iTBS) to see if it’s doable, safe, and tolerable for adults with PTSD and major depression.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT07682207

• Type D Personality and Life Satisfaction in Bipolar II and Major Depressive Disorder

  This study tests how Type D personality relates to life satisfaction in adults with Bipolar II or Major Depressive Disorder and in healthy controls.

  Recruiting Elazığ Mental Health and Diseases Hospital · Elâzığ · NCT07679204

• Sertraline with multi-strain probiotics for adolescents with depression

  This study tests whether adding multi-strain probiotics to sertraline helps teens (ages 12–18) with major depressive disorder feel better than sertraline with a placebo.

  Recruiting Phase 2 First Affiliated Hospital of Chongqing Medical University · Chongqing, Yuzhong · NCT07645157

• TNX-102 SL taken at night for major depressive disorder

  A nighttime dose of TNX-102 SL is being tested to see if it helps adults with moderate to severe major depressive disorder compared to a placebo.

  Recruiting at 26 sites Phase 2 Tonix Pharmaceuticals, Inc. · Phoenix, Arizona and 26 other locations · NCT07621237

• DT-101 as an extra treatment for adults with major depressive disorder

  This study tests whether DT-101 added to current antidepressant treatment helps adults with major depressive disorder more than a placebo over 8 weeks.

  Recruiting at 23 sites Phase 2 Draig Therapeutics Ltd · Phoenix, Arizona and 22 other locations · NCT07610473

• CIDI 5.0 validation against SCID-5 for lifetime mental disorders in Hong Kong adults

  This study tests whether the CIDI 5.0 interview can reliably identify lifetime mental disorders in adults in Hong Kong by comparing it with the SCID-5 diagnostic interview.

  Recruiting The University of Hong Kong · Hong Kong · NCT07604753

• Accelerated bilateral DMPFC iTBS for major depression

  This study tests whether a fast, multiple-daily session brain stimulation approach can help adults with major depressive disorder who have not fully benefited from standard antidepressants.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT07603804

• How urban stress patterns relate to mental illness in adults

  This study tests whether real-time environmental stress in cities is linked to depression, anxiety, or alcohol use disorders in adults 18–60 who wear a wrist sensor and use a study app.

  Recruiting at 3 sites Huashan Hospital · Beijing and 2 other locations · NCT07571226

• Ketamine with DBT for suicidality in adults with treatment-resistant depression or bipolar disorder and BPD

  This study tests whether four ketamine infusions plus Dialectical Behavioural Therapy can more quickly reduce suicidal thoughts in adults with Borderline Personality Disorder and treatment-resistant depression or bipolar disorder.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07569198

• Inhaled DMT for major depressive disorder

  This trial tests whether inhaled DMT can quickly ease depressive symptoms and reduce suicide risk in adults with major depressive disorder.

  Recruiting Phase 2 Universidade Federal do Rio Grande do Norte · Fortaleza, Ceará and 4 other locations · NCT07562191

• Sertraline plus a probiotic (Lactobacillus crispatus) for teens with depression

  This study tests whether adding Lactobacillus crispatus to sertraline helps reduce depressive symptoms in adolescents with major depressive disorder.

  Recruiting Phase 2 First Affiliated Hospital of Chongqing Medical University · Longgang, Chongqing Municipality and 1 other locations · NCT07539805

• How brain function changes after brain stimulation in depression treated with ECT or MST

  This study tests whether electroconvulsive therapy or magnetic seizure therapy, paired with a quick brain scan (fNIRS), can reveal brain function changes in people with major depressive disorder.

  Recruiting The Second Hospital of Anhui Medical University · Hefei, Anhui · NCT07533773

• Dextromethorphan‑bupropion effects on reward-related brain activity in adults with depression

  This two-week treatment gives adults with moderate-to-severe depression a combined dextromethorphan‑bupropion pill to see if it changes how their brain responds to reward on fMRI.

  Recruiting Phase 2 Brain and Cognition Discovery Foundation · Toronto, Ontario · NCT07523048

• Bright light therapy for cognitive problems in major depression

  A randomized trial will test whether bright light therapy can improve thinking problems in adults with major depressive disorder who are on SSRIs or off medications.

  Recruiting at 2 sites Peking University Sixth Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07508215

• 7T MRI and visual perception markers for severe mood and psychotic disorders

  This project tests whether 7‑tesla MRI scans combined with visual perception tests can identify brain markers linked to diagnosis and treatment outcomes in adults with major depressive disorder, bipolar disorder, or schizophrenia.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07479758

• Gender differences in depression symptoms, resilience, and stigma among adults with major depression

  This project will look to see if men and women with major depressive disorder show different symptom patterns, resilience levels, and experiences of self and social stigma.

  Recruiting Eskisehir Osmangazi University · Eskişehir, Eskişehir · NCT07474363

• Lifestyle interventions to prevent cognitive decline in people with major depression

  This project tests whether regular physical activity, cognitive training, and omega-3 dietary supplements can reduce depression symptoms and delay thinking problems in people aged 50–80 with major depressive disorder.

  Recruiting National Science and Technology Council, Taiwan · Taichung, Taichung · NCT07462013

• Psilocybin-assisted Therapy for people with both major depressive disorder and alcohol use disorder

  This study tests whether psilocybin-assisted therapy can be safely used and help people who have both depression and alcohol use problems.

  Recruiting Phase 2 Centre for Addiction and Mental Health · Toronto, Ontario · NCT07405606

• VR pupillometry to detect cognitive impairment

  This project will try VR-based eye-tracking pupillometry to see if pupil responses can detect and track cognitive problems in adults with Alzheimer's, mild cognitive impairment, depression-related cognitive impairment, or no cognitive issues.

  Recruiting Max-Planck-Institute of Psychiatry · München, Bavaria · NCT07402356

• Group therapy comparing expectation-focused and reward-focused approaches for major depression

  This trial tests whether two group psychotherapies—one that challenges rigid negative expectations and one that increases sensitivity to positive rewards—help adults with major depressive disorder feel less depressed than a wait-list.

  Recruiting Philipps University Marburg · Marburg, Hesse · NCT07388004

• Ketogenic Diet with Accelerated Brain Stimulation for Treatment‑Resistant Depression

  This study tests whether adding a ketogenic diet to a personalized accelerated brain stimulation treatment helps reduce depression symptoms in adults with treatment‑resistant depression.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07376018

• Brain and genetic tests to predict relapse in depression

  This project will test whether people with major depressive disorder can safely stop antidepressants once their brain and genetic measures look normal.

  Recruiting Uskudar University · Istanbul · NCT07328373

• Electroconvulsive therapy combined with transcranial magnetic stimulation for treatment-resistant depression

  This will test whether giving a short burst of intermittent theta-burst magnetic stimulation (iTBS) just before electroconvulsive therapy helps adults with treatment-resistant major depressive disorder by lowering the energy needed to trigger a therapeutic seizure.

  Recruiting Charles University, Czech Republic · Prague, Czech · NCT07324070

• DT-101 for adults with recurrent major depressive disorder

  This trial will test whether DT-101 helps adults with recurrent major depressive disorder compared with a placebo.

  Recruiting at 40 sites Phase 2 Draig Therapeutics Ltd · Bentonville, Arkansas and 42 other locations · NCT07300969

• ACP-211 alone for adults whose depression hasn't improved with antidepressants

  This trial tests whether ACP-211 can help adults with major depressive disorder who haven't improved on antidepressants do better than a placebo.

  Recruiting at 24 sites Phase 2 ACADIA Pharmaceuticals Inc. · Birmingham, Alabama and 27 other locations · NCT07284667

• Multimodal phenotyping in adolescents hospitalized for depression

  This project will collect brain scans, blood tests, sleep and activity signals, and psychological test results from hospitalized teens with major depressive episodes to try to find patterns that predict treatment response and cognitive or emotional problems.

  Recruiting Jiangsu Province Nanjing Brain Hospital · Nanjing, Jiangsu · NCT07247344

• Right orbitofrontal cortex TMS for depression

  This study tests whether active transcranial magnetic stimulation to the right orbitofrontal cortex can lessen depressive symptoms in adults with moderate to severe major depressive disorder, compared with sham stimulation.

  Recruiting Harvard University Faculty of Medicine · Boston, Massachusetts · NCT07230990

• Home-based transcranial direct current stimulation for major depression

  This trial will test whether using a small brain-stimulation device at home (tDCS) together with usual care helps adults with moderate-to-severe major depressive disorder feel better over a 10-week treatment and up to six months of follow-up.

  Recruiting King's College London · Cardiff and 5 other locations · NCT07228468

• Double-blind, placebo-controlled test of SPN-821 in adults with major depressive disorder

  This trial will test whether adding SPN-821 twice weekly to an approved antidepressant helps adults with major depressive disorder who have not had enough improvement.

  Recruiting at 40 sites Phase 2 Supernus Pharmaceuticals, Inc. · Birmingham, Alabama and 39 other locations · NCT07226661

• Deep TMS for adolescents hospitalized with depression

  This trial will try deep transcranial magnetic stimulation (dTMS) as an add-on to usual care for 14–18-year-olds hospitalized with major depressive disorder to see if it reduces depressive symptoms, suicidal thoughts, and readmissions.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07217444

• At-home spaced transcranial direct current stimulation for treatment-resistant depression

  This will test whether a two-week program of at-home spaced transcranial direct current stimulation (tDCS) can help people with treatment-resistant depression who have not improved on antidepressants.

  Recruiting University of California, San Diego · San Diego, California · NCT07217223

• Accelerated deep TMS targeting the anterior cingulate for depression in older adults

  This study will test whether a 5-day accelerated deep TMS treatment aimed at the anterior cingulate can reduce depression in people aged 60–85 who have not tolerated or responded to antidepressants.

  Recruiting Rotman Research Institute at Baycrest · Toronto, Ontario · NCT07212465

• Ear vagus nerve stimulation to improve motivation and insulin sensitivity

  This trial will test whether short sessions of non-invasive ear vagus nerve stimulation can improve motivation and mood in adults with major depression and whether a person’s insulin sensitivity changes those effects.

  Recruiting University of Bonn · Bonn · NCT07198100

• Real-time fMRI neurofeedback to reduce negative attention bias in depression

  This trial will see if cloud-based real-time fMRI neurofeedback can reduce negative attention bias and improve depressive symptoms in adults with major depressive disorder who are not taking psychiatric medications.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07159061

• Pattern separation in major depressive disorder: adding memantine to an SSRI

  This study tests whether adding extended-release memantine to an SSRI helps people with major depressive disorder see if their memory and brain activity improve and depressive symptoms get better.

  Recruiting Phase 1 New York State Psychiatric Institute · New York, New York · NCT07139834

• Four-day accelerated deep TMS after ECT for severe depression

  This project will try a four-day course of accelerated deep TMS (20 sessions) to see if it helps adults with major depressive disorder who did not improve after standard ECT.

  Recruiting Universitair Ziekenhuis Brussel · Jette, Brussels Capital · NCT07115628

• Conversations AI for Depression Care: Hearing Patient Voices in MDD

  A home-based conversational AI intake is tested to see if it changes how patients with major depressive disorder feel about the empathy they receive compared with usual care.

  Recruiting George Mason University · Fairfax, Virginia · NCT07105397

• PET with [18F]VAT to see how nicotine affects brain acetylcholine in depression

  We will use PET scans with the [18F]VAT tracer to see if a nicotine patch changes acetylcholine-related brain signals in adults with major depressive disorder.

  Recruiting Phase 4 Stony Brook University · Stony Brook, New York · NCT07095205

• mGluR5 and sleep-focused CBT for depression

  This trial will test whether an online sleep program (CBT-I) changes brain mGluR5 levels and improves sleep and depression in adults with moderate-to-severe major depressive disorder.

  Recruiting Phase 4 Stony Brook University · Stony Brook, New York · NCT07076342

• SPT-300 (GlyphAllo) for adults with major depressive disorder, with or without anxious distress

  This will test whether a single medication, SPT-300 (GlyphAllo), is effective and safe for adults 18–65 who have major depressive disorder, with or without anxious distress.

  Recruiting at 56 sites Phase 2 Seaport Therapeutics · Chino, California and 61 other locations · NCT07065240

• EEG neurofeedback to improve emotion regulation in major depression

  This trial will test whether EEG-based neurofeedback can help adults with major depressive disorder, including those with anxiety symptoms, improve emotion regulation and reduce depressive symptoms after not responding well to first-line treatments.

  Recruiting Corporacion Parc Tauli · Sabadell, Barcelona, Cataluña · NCT07041073

• Theta-burst stimulation for depression

  This trial tests two timing schedules of intermittent theta-burst stimulation (a quick form of TMS) to see which better improves brain plasticity and reduces depressive symptoms in adults 18–50 with major depressive disorder.

  Recruiting Phase 1 Centre for Addiction and Mental Health · Toronto, Ontario · NCT07033780

• Accelerated intermittent theta burst stimulation for adolescents and young adults with depression and suicidal thoughts

  This trial will try a fast, noninvasive, MRI-guided brain stimulation (accelerated intermittent theta burst TMS) given over five days to reduce depression and suicidal thoughts in 15–25 year olds recently treated for suicidality.

  Recruiting University of California, Davis · Sacramento, California · NCT07025720

• Moving on After Breast Cancer: support for breast cancer survivors with depression in Pakistan

  This trial will test a three-stage adaptive program to see if it helps breast cancer survivors in Pakistan who have major depression feel better and lowers care costs.

  Recruiting Pakistan Institute of Living and Learning · Karachi, Sindh · NCT07015944

• Lifestyle changes to prevent memory problems in older adults with depression

  This trial will test whether a Mediterranean-style diet, regular supervised exercise, or weekly cognitive training can help prevent memory decline and improve mood in people aged 50–80 with depressive symptoms or major depression but no cognitive impairment.

  Recruiting IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia · NCT07009223

• Healthy-lifestyle program to help with depression using the Mediterranean diet and activity

  This trial tests whether combining Mediterranean diet lessons with a structured physical activity program can help reduce depressive symptoms in people with major depressive disorder.

  Recruiting at 2 sites IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia, Italy and 1 other locations · NCT06990035

• Physical therapy to improve quality of life in major depression

  This program will try twice-weekly physical therapy sessions with exercises and health education to see if adults admitted for major depressive disorder in a short-stay psychiatric unit have better quality of life.

  Recruiting Universidad San Jorge · Zaragoza, Aragon · NCT06983405

• At-home brain stimulation treatment for major depression

  This study is testing a new at-home brain stimulation treatment to see if it can help people with major depression feel better.

  Recruiting Sooma Medical Inc · Boston, Massachusetts · NCT06976697

• Home-based transcranial direct current stimulation (tDCS) for depression in borderline personality disorder

  This project will see if 14 home-based tDCS sessions, compared with sham, can reduce depressive symptoms in adults with borderline personality disorder and moderate-to-severe depression.

  Recruiting Ciusss de L'Est de l'Île de Montréal · Montreal, Quebec · NCT06972368

• Evaluating Dextromethorphan and Bupropion for Major Depression

  This study is testing if a new combination of two medications, dextromethorphan and bupropion, can help adults with major depression feel better compared to a placebo.

  Recruiting Phase 3 CSPC Ouyi Pharmaceutical Co., Ltd. · Beijing, Beijing Municipality · NCT06958692

• Treating suicidal thoughts in depression with ketamine

  This study is testing if ketamine can help people with major depression who are having suicidal thoughts feel better by giving them infusions over two weeks while also looking at their brain activity and experiences.

  Recruiting Phase 2/3 The Royal's Institute of Mental Health Research · Ottawa, Ontario · NCT06891300

• EmoDTx mood-monitoring app for adults with unipolar depression

  This project will test whether the EmoDTx app, which analyzes facial expressions, can track mood in adults with unipolar depression and align with standard questionnaires.

  Recruiting at 2 sites Emobot · Changé, France and 1 other locations · NCT06860165

• Suvorexant (an orexin blocker) for suicide risk in veterans with major depressive disorder

  This trial will try daily suvorexant for four weeks to see if it is safe and tolerable for veterans with major depressive disorder who have had suicidal thoughts or attempts.

  Recruiting Phase 2 Bronx Veterans Medical Research Foundation, Inc · The Bronx, New York · NCT06854224

• Evaluating milsaperidone for treating major depressive disorder

  This study is testing if adding milsaperidone to the treatment plan can help people with major depressive disorder who haven't felt better with their current antidepressants.

  Recruiting at 50 sites Phase 3 Vanda Pharmaceuticals · Phoenix, Arizona and 52 other locations · NCT06830044

• Assessing mental health disorders in Hong Kong using a new recall method

  This study is testing a new way to help people in Hong Kong remember important life events to see how many have experienced major depression and thoughts of suicide.

  Recruiting The University of Hong Kong · Hong Kong · NCT06804525

• CYB003, a deuterated psilocin, for adults with major depressive disorder

  This trial will test whether adding CYB003 to a current antidepressant helps reduce symptoms in adults with major depressive disorder who have not responded well to their medication.

  Recruiting at 51 sites Phase 3 Cybin IRL Limited · Birmingham, Alabama and 78 other locations · NCT06793397

• Measuring glutamate changes after ketamine to explain its fast antidepressant effects

  This trial will see if ketamine produces measurable changes in brain glutamate in adults with treatment-resistant major depressive disorder using high-field GluCEST imaging.

  Recruiting Early Phase 1 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06788249

• Psilocybin therapy for depression and existential distress in people with COPD, ALS, MS, or atypical Parkinson disease

  This trial will test whether psilocybin therapy can reduce depression and psychological distress in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least six months expected life.

  Recruiting at 4 sites Phase 2 University Medical Center Groningen · Prague and 3 other locations · NCT06782724

• Exercise priming before rTMS (iTBS) for difficult-to-treat depression

  This will test whether adding a 4-week structured exercise program before and during intermittent theta-burst stimulation (iTBS) helps physically inactive adults with treatment-resistant depression feel better.

  Recruiting The Royal Ottawa Mental Health Centre · Ottawa, Ontario · NCT06773949

• Understanding relapse in major depressive disorder

  This study is trying to find out what factors can help predict when people with major depressive disorder might relapse so that doctors can better prevent it.

  Recruiting at 8 sites Nova Scotia Health Authority · Calgary, Alberta and 8 other locations · NCT06746155

• Digital health tools for adults with treatment-resistant depression

  This study is testing if digital health tools, like apps and wearable devices, can help adults with treatment-resistant depression track their symptoms and treatment responses while they receive care.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT06732089

• Group cognitive rehabilitation for Veterans with depression-related thinking problems

  This trial tests whether an 8-week group program that teaches compensatory thinking strategies with motivational and mindfulness supports can help Veterans treated for major depression who still have memory, attention, or other thinking problems.

  Recruiting Portland VA Medical Center · Portland, Oregon · NCT06728774

• Using fecal microbiota transplantation to treat major depressive disorder

  This study is testing if a treatment using gut bacteria from healthy donors can help people with major depressive disorder who haven't responded well to their current antidepressants feel better.

  Recruiting at 8 sites Capital Medical University · Wuhu, Anhui and 8 other locations · NCT06692361

• Investigating dopamine changes in healthy and depressed individuals

  This study is testing how two different antidepressants affect dopamine levels in the brains of people with depression compared to healthy individuals to better understand how depression works.

  Recruiting Phase 4 Medical University of Vienna · Vienna · NCT06675851

• Evaluating an emotional monitoring device for depression assessment

  This study is testing a new emotional monitoring app to see if it can give reliable results for people with mild to moderate depression compared to traditional questionnaires.

  Recruiting at 6 sites Emobot · Agen and 10 other locations · NCT06601140

• Psychoeducational program for treating depression

  This study tests if adding a six-week group program that teaches coping strategies can help people with Major Depressive Disorder feel better and improve their quality of life.

  Recruiting University of Sao Paulo · São Paulo · NCT06467474

• Comparing Magnetic Seizure Therapy and Electroconvulsive Therapy for Major Depression

  This study is testing whether Magnetic Seizure Therapy works better than Electroconvulsive Therapy for treating major depression.

  Recruiting Shanghai Mental Health Center · Shanghai, Shanghai Municipality · NCT06409325

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using magnetic stimulation to treat depression and pain together

  This study is looking at a new way to help people with both depression and chronic pain by using a special treatment called rTMS, which targets different parts of the brain to improve mood and reduce pain.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10817712

Related topics

Quick answers

How many Major Depressive Disorder (MDD) clinical trials are recruiting right now?

78, as of November 12, 2026. 5 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 26 countries. The most sites are in United States (24 trials), Canada (13 trials), China (11 trials), Czechia (6 trials), Germany (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 16, Phase 4: 3, Phase 3: 3, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →