Conversations AI for Depression Care: Hearing Patient Voices in MDD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares a conversational AI intake with standard clinical intake in adults with moderate to severe major depressive disorder. Participants complete the AI intake at home and then experience usual care, with the order randomized to minimize sequence effects. Each participant serves as their own control, and outcomes focus on perceived empathy during clinical interactions over four months. The approach uses an advanced AI system guided by a structured knowledge network and a novel patient-simulator framework to ensure relevant, coherent conversations. The trial addresses safety, reliability, and the potential to streamline antidepressant decision-making in real-world settings.

Why it matters

Who can join: the full rules

1. Participant is between 18 to 85 years old.
2. Participant has been, or are likely to be, diagnosed with moderate to severe Major Depressive Disorder without signs of bipolar depression.
3. Participant is not in active suicidal crisis and do not face imminent risk of suicide within the next 3 hours.
4. Participant is not pregnant or seeking to be pregnant.
5. Participant able to communicate in English on the Internet.
6. Participant must reside in the United States.
7. Participant has access to a mental health clinician, or the participant is willing to see study clinicians to help review the advice and medication adjustments recommended by the AI Intake System to the participant.
8. If the participant is seeing study clinicians, the participant must reside in a state where study clinicians are licensed.
9. Participant must be using a device (phone or computer) that is located in the United States.

Where it's running

• George Mason University
  Fairfax, Virginia, United States Recruiting

Study contacts

• Study coordinator: Farrokh Alemi, PhD
• Email: rapidai@gmu.edu
• Phone: 7579459484

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.