How brain function changes after brain stimulation in depression treated with ECT or MST

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses resting-state and task-based functional near-infrared spectroscopy to observe brain hemodynamics before and after treatment with electroconvulsive therapy or magnetic seizure therapy in adults with major depressive disorder. It aims to compare how these two neuromodulation approaches affect frontotemporal brain function and related cognitive processes. The study emphasizes the potential of a simple, noninvasive assessment method to complement cognitive testing and understand treatment-related brain changes. Eligible participants have a current depressive episode, adequate education, and consent to participate, with exclusions for certain co-morbid conditions and recent ECT/MST exposure. The study is led by The Second Hospital of Anhui Medical University in Hefei, China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A depressive episode diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by two psychiatrists;
* Meets the treatment criteria for ECT or MST;
* At least 5 years of education, with no significant hearing or visual impairments;
* Voluntary participation in this study, with a signed written informed consent form, and willingness to cooperate with the collection of general demographic information, neuropsychological testing, and fNIRS resting-state and task-based data acquisition.

Exclusion Criteria:

* Co-occurring mental disorders (such as substance use disorders or schizoaffective disorder);
* Severe physical illness;
* History of neurological disorders (such as traumatic brain injury or dementia);
* Low educational attainment;
* Receipt of ECT or MST treatment within the past six months.

Where it's running

• The Second Affiliated Hospital of Anhui Medical University
  Hefei, Anhui, China Recruiting

Study contacts

• Study coordinator: Yanghua Tian
• Email: tianyh@ahmu.edu.cn
• Phone: +86-13955188448

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.