Accelerated intermittent theta burst stimulation for adolescents and young adults with depression and suicidal thoughts

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This open-label interventional protocol delivers accelerated intermittent theta burst stimulation (iTBS), a form of MRI-guided transcranial magnetic stimulation, across five consecutive days to participants aged 15–25 with major depressive disorder and recent suicidal ideation. All participants receive MRI scans before and after the treatment course and complete clinical assessments at baseline, 1 week, and 4 weeks post-treatment. Primary outcomes include feasibility and acceptability, with measures of depressive symptoms, suicidal ideation, hospitalization rates, and daily functioning as secondary outcomes. No surgical procedures or investigational drugs are involved.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* English speaking
* Able to provide informed consent
* age 15-25 years
* Discharged within the past week from the ED for chief complaint of SI OR recently admitted in urgent health care setting or seen in outpatient clinic for depression-related suicidal ideation
* Meets MDD criteria per the Mini International Neuropsychiatric Interview (MINI)

Exclusion Criteria:

* Unable to consent (due to medical condition, psychosis, substance use, etc)
* Use of benzodiazepines or medications that would interfere with TMS treatment as per PI discretion
* Active substance use or severe substance use that in the opinion of the PI would interfere with study participation
* Untreated, active psychosis
* Female patient who is breastfeeding, pregnant or who is planning a pregnancy during the study
* Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies
* Contraindications to receiving TMS and/or MRI as determined by screening questionnaires

Where it's running

• UC Davis Medical Center
  Sacramento, California, United States Recruiting

Study contacts

• Study coordinator: Se Ri (Sally) Bae, MD
• Email: sebae@ucdavis.edu
• Phone: 213-340-4006

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.