Gender differences in depression symptoms, resilience, and stigma among adults with major depression
Official title: A Comparative Examination of Depression Severity, Gender-Sensitive Depressive Symptoms, Psychological Resilience, and Stigma Levels in Women and Men With Major Depressive Disorder
Run by Eskisehir Osmangazi University · NCT07474363 · Data updated 2026-11-12
This project will look to see if men and women with major depressive disorder show different symptom patterns, resilience levels, and experiences of self and social stigma.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Eskisehir Osmangazi University Academic / other |
| Locations | 1 site (Eskişehir, Eskişehir) |
| Status | Recruiting |
| Started | June 1, 2025 |
| Main results expected | April 2026 |
| Study ends | November 2026 |
| Registry record updated | March 25, 2026 |
| Trial ID | NCT07474363 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 to 65 with a current DSM-5 diagnosis of Major Depressive Disorder who can provide informed consent and attend the outpatient clinic are ideal candidates.
✕Probably not a fit
People with intellectual disability, severe neurological disorders, other comorbid psychiatric diagnoses, depression caused by a medical condition or substance use, or those outside the 18–65 age range will not be eligible and are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational, cross-sectional study of adults aged 18–65 diagnosed with Major Depressive Disorder at the Psychiatry Outpatient Clinic of Eskişehir Osmangazi University. Participants who consent will complete clinical interviews and standardized questionnaires measuring depression severity, gender-sensitive symptom profiles, psychological resilience, self-stigma, and perceived social stigma. People with intellectual disability, severe neurological disorders, other psychiatric comorbidities, or depression secondary to medical conditions or substance use are excluded. The data will be analyzed to compare symptom expression and stigma/resilience patterns between male and female participants and explore relationships between these factors.
Why it matters
Potential benefit: If successful, the findings could help clinicians recognize gender-specific symptom patterns and stigma-related barriers so care and outreach can be better tailored.
How similar studies have gone: Previous research has documented gender differences in depressive symptom expression and stigma, though combining detailed gender-sensitive symptom profiling with resilience and stigma measures in a single outpatient sample is less common.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female patients aged 18 to 65 years * Diagnosis of Major Depressive Disorder according to DSM-5 at the time of study participation * Provision of voluntary informed consent Exclusion Criteria: * Intellectual disability * Severe neurological disorders * Comorbid psychiatric diagnoses * Depressive disorder secondary to an organic medical condition * Depressive disorder secondary to substance use
Where it's running
-
the Department of Psychiatry Outpatient Clinic at Eskişehir Osmangazi University Faculty of Medicine
Eskişehir, Eskişehir, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: İrem OZKAYNAK DAGLİ, Research assistant, M.D.
- Email: irem.ozkaynak@ogu.edu.tr
- Phone: +90 0222 239 29 79
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.