Lifestyle interventions to prevent cognitive decline in people with major depression
Official title: Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice (POWER)
Run by National Science and Technology Council, Taiwan · NCT07462013 · Data updated 2026-11-12
This project tests whether regular physical activity, cognitive training, and omega-3 dietary supplements can reduce depression symptoms and delay thinking problems in people aged 50–80 with major depressive disorder.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years to 80 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | National Science and Technology Council, Taiwan Government |
| Locations | 1 site (Taichung, Taichung) |
| Status | Recruiting |
| Started | October 1, 2025 |
| Main results expected | June 2028 |
| Study ends | September 2028 |
| Registry record updated | June 17, 2026 |
| Trial ID | NCT07462013 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people aged 50–80 with a diagnosis of major depressive disorder and absence or only mild cognitive impairment who can participate in exercise, cognitive training, and take supplements.
✕Probably not a fit
People with moderate-to-severe cognitive impairment, significant uncontrolled medical or psychiatric conditions, or those unable to attend in-person visits or follow the intervention regimen may not receive benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
POWER is a randomized, controlled, non-profit project testing non-pharmacological approaches—structured physical activity, targeted cognitive training, and supplementation with eicosapentaenoic acid (an omega‑3)—compared with a soybean oil standard treatment. Eligible participants are adults aged 50–80 with diagnosed major depressive disorder and no more than mild cognitive impairment. The trial measures changes in depressive symptoms and cognitive performance over the intervention period using standardized assessments. The study is run from the Mind Body Interface Research Center in Taichung, Taiwan with international collaborators.
Why it matters
Potential benefit: If successful, these low-risk lifestyle interventions could reduce depressive symptoms and lower the risk or delay the onset of cognitive impairment in older adults with depression.
How similar studies have gone: Previous trials have shown modest benefits from exercise, cognitive training, or omega‑3 supplementation individually, but combining these approaches specifically in people with MDD is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 50-80 years old * Major Depressive Disorder * Absence or mild cognitive impairment Exclusion Criteria: \-
Where it's running
-
Mind Body Interface Research Center (MBI Lab & Care)
Taichung, Taichung, Taiwan Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.