EEG microstates and inflammatory markers in treatment-resistant depression patients undergoing ECT

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will collect EEG data before and after ECT to analyze microstate patterns, which may reflect changes in large-scale brain networks. Blood samples will be drawn to measure inflammatory markers and blood counts before and after treatment. The goal is to see if changes in EEG microstates correlate with clinical improvement and biomarker shifts in patients with resistant major depression, compared with healthy controls.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patient Group

* Age 18-60 years
* Diagnosis of Major Depressive Disorder, current major depressive episode, according to DSM-5 criteria.
* Clinical indication for electroconvulsive therapy (ECT).
* Ability to provide written informed consent.
* Willingness to participate in the study.

Healthy Control Group:

* Age ≥55 years.
* No current psychiatric disorder.
* No known neurological disorder.
* Good general physical health.
* No current use of medications known to affect EEG activity or inflammatory biomarkers significantly.
* Ability to provide written informed consent.
* Willingness to participate in the study.

Exclusion Criteria:

* Primary neurological disorders (e.g., dementia or traumatic brain injury).
* Schizophrenia or other psychotic disorders.
* Bipolar disorder diagnosis,
* Intracranial space-occupying lesions.
* Increased intracranial pressure.
* Myocardial infarction within the previous 3 months.
* Cerebrovascular disease within the previous month.
* Unstable cerebral aneurysm.
* Pheochromocytoma.
* Electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS) within the previous month.
* Cognitive impairment severe enough to prevent adequate cooperation during EEG recording.
* Current alcohol or substance use disorder.
* Active infectious disease.
* Autoimmune or chronic inflammatory disorders.
* Current use of systemic corticosteroids, immunosuppressive agents, or other medications known to affect inflammatory biomarkers significantly.

Where it's running

• İstanbul University- Cerrahpasa, Cerrahpasa Medicine Faculty, Psychiatry Department
  Istanbul, Bakırköy, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Zeynep Özge Dagoglu Sarac, Dr
• Email: zod395@gmail.com
• Phone: +905365942469

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• EEG microstates and inflammatory biomarkers in older adults with major depression receiving ECT

  This study tests how ECT affects brain wave patterns and inflammatory markers in people 55 and older with major depression.

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• EEG-Guided TMS for Adults With Depression

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• EEG neurofeedback to improve emotion regulation in major depression

  This trial will test whether EEG-based neurofeedback can help adults with major depressive disorder, including those with anxiety symptoms, improve emotion regulation and reduce depressive symptoms after not responding well to first-line treatments.

  Recruiting Corporacion Parc Tauli · Sabadell, Barcelona, Cataluña · NCT07041073

• Digital health tools for adults with treatment-resistant depression

  This study is testing if digital health tools, like apps and wearable devices, can help adults with treatment-resistant depression track their symptoms and treatment responses while they receive care.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT06732089

• Registry for patients with treatment-resistant depression and OCD receiving interventional therapies

  This study is testing different treatments like ECT, TMS, and ketamine to see how they help people with treatment-resistant depression and OCD feel better.

  Recruiting University of Iowa · Iowa City, Iowa · NCT04480918

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.