Investigating how a protein affects liver failure during sepsis
The role of C/EBPß in sepsis associated acute-on-chronic liver failure
This study is looking at how infections can suddenly worsen liver problems in people who already have liver issues, using a special mouse model to explore how certain proteins affect liver health, with the hope of finding better treatments for those affected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11134516 on NIH RePORTER |
What this research studies
This research focuses on understanding acute-on-chronic liver failure (ACLF), particularly how sepsis can lead to sudden liver dysfunction in patients with pre-existing liver conditions. Using a newly developed mouse model, the study examines the role of C/EBPβ and angiopoietins in liver cell function and survival during sepsis. By analyzing the changes in liver function and cell signaling pathways, the research aims to uncover the mechanisms behind ACLF and identify potential therapeutic targets. Patients may benefit from insights that could lead to improved treatments for liver failure associated with sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic liver disease who are at risk of developing acute-on-chronic liver failure due to sepsis.
Not a fit: Patients with acute liver failure not associated with chronic liver disease or sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve liver function and survival rates in patients experiencing sepsis-related liver failure.
How similar studies have performed: While there has been limited mechanistic research on ACLF, the use of animal models to study similar conditions has shown promise in understanding liver dysfunction.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Tikhanovich, Irina — University of Kansas Medical Center
- Study coordinator: Tikhanovich, Irina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.